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- NCIT_C84836 IAO_0000115 "An orally bioavailable, synthetic, second-generation small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor LAM-003A selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; this agent may inhibit the growth and survival of a wide variety of cancer cell types. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability, and degradation of many oncogenic signaling proteins." @default.
- NCIT_C84836 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84836 NCIT_NHC0 "C84836" @default.
- NCIT_C84836 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84836 NCIT_P108 "Hsp90 Inhibitor LAM-003A" @default.
- NCIT_C84836 NCIT_P207 "C2830123" @default.
- NCIT_C84836 NCIT_P210 "958025-66-6" @default.
- NCIT_C84836 NCIT_P319 "9UMA2EEO9Q" @default.
- NCIT_C84836 NCIT_P322 "FDA" @default.
- NCIT_C84836 NCIT_P322 "GDC" @default.
- NCIT_C84836 NCIT_P329 "649142" @default.
- NCIT_C84836 NCIT_P330 "649142" @default.
- NCIT_C84836 NCIT_P375 "Hsp90 Inhibitor MPC-3100" @default.
- NCIT_C84836 NCIT_P399 "649142" @default.
- NCIT_C84836 NCIT_R125 NCIT_C17828 @default.
- NCIT_C84836 NCIT_R125 NCIT_C20150 @default.
- NCIT_C84836 NCIT_R125 NCIT_C20480 @default.
- NCIT_C84836 NCIT_R125 NCIT_C40715 @default.
- NCIT_C84836 NCIT_R125 NCIT_C41515 @default.
- NCIT_C84836 NCIT_R125 NCIT_C51037 @default.
- NCIT_C84836 normalizedInformationContent "100" @default.
- NCIT_C84836 referenceCount "1" @default.
- NCIT_C84836 hasExactSynonym "Hsp90 Inhibitor LAM-003A" @default.
- NCIT_C84836 hasExactSynonym "LAM 003A" @default.
- NCIT_C84836 hasExactSynonym "LAM-003A" @default.
- NCIT_C84836 hasExactSynonym "LAM003A" @default.
- NCIT_C84836 hasExactSynonym "MPC-3100" @default.
- NCIT_C84836 inSubset NCIT_C128784 @default.
- NCIT_C84836 inSubset NCIT_C157711 @default.
- NCIT_C84836 inSubset NCIT_C157712 @default.
- NCIT_C84836 inSubset NCIT_C176424 @default.
- NCIT_C84836 inSubset NCIT_C177537 @default.
- NCIT_C84836 inSubset NCIT_C63923 @default.
- NCIT_C84836 type Class @default.
- NCIT_C84836 isDefinedBy ncit.owl @default.
- NCIT_C84836 label "Hsp90 Inhibitor LAM-003A" @default.
- NCIT_C84836 subClassOf NCIT_C129824 @default.
- NCIT_C84836 subClassOf NCIT_C156880 @default.
- NCIT_C84836 subClassOf NCIT_C1908 @default.
- NCIT_C84836 subClassOf NCIT_C1909 @default.
- NCIT_C84836 subClassOf NCIT_C2189 @default.
- NCIT_C84836 subClassOf NCIT_C274 @default.
- NCIT_C84836 subClassOf NCIT_C74526 @default.
- NCIT_C84836 subClassOf NCIT_C84836 @default.