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- NCIT_C84837 IAO_0000115 "An agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor PF-04691502 inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K." @default.
- NCIT_C84837 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84837 NCIT_A7 NCIT_C17270 @default.
- NCIT_C84837 NCIT_NHC0 "C84837" @default.
- NCIT_C84837 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84837 NCIT_P107 "PI3K/mTOR Kinase Inhibitor PF-04691502" @default.
- NCIT_C84837 NCIT_P108 "PI3K/mTOR Kinase Inhibitor PF-04691502" @default.
- NCIT_C84837 NCIT_P207 "C2827515" @default.
- NCIT_C84837 NCIT_P210 "1013101-36-4" @default.
- NCIT_C84837 NCIT_P319 "4W39NS61KI" @default.
- NCIT_C84837 NCIT_P322 "CTRP" @default.
- NCIT_C84837 NCIT_P322 "FDA" @default.
- NCIT_C84837 NCIT_P322 "GDC" @default.
- NCIT_C84837 NCIT_P329 "649523" @default.
- NCIT_C84837 NCIT_P330 "649523" @default.
- NCIT_C84837 NCIT_P375 "PI3K/mTOR Kinase Inhibitor PF-04691502" @default.
- NCIT_C84837 NCIT_P399 "649523" @default.
- NCIT_C84837 normalizedInformationContent "100" @default.
- NCIT_C84837 referenceCount "1" @default.
- NCIT_C84837 hasExactSynonym "PF-04691502" @default.
- NCIT_C84837 hasExactSynonym "PI3K/mTOR Kinase Inhibitor PF-04691502" @default.
- NCIT_C84837 inSubset NCIT_C116977 @default.
- NCIT_C84837 inSubset NCIT_C116978 @default.
- NCIT_C84837 inSubset NCIT_C128784 @default.
- NCIT_C84837 inSubset NCIT_C157711 @default.
- NCIT_C84837 inSubset NCIT_C157712 @default.
- NCIT_C84837 inSubset NCIT_C176424 @default.
- NCIT_C84837 inSubset NCIT_C177537 @default.
- NCIT_C84837 inSubset NCIT_C63923 @default.
- NCIT_C84837 type Class @default.
- NCIT_C84837 isDefinedBy ncit.owl @default.
- NCIT_C84837 label "PI3K/mTOR Kinase Inhibitor PF-04691502" @default.
- NCIT_C84837 subClassOf NCIT_C129824 @default.
- NCIT_C84837 subClassOf NCIT_C129825 @default.
- NCIT_C84837 subClassOf NCIT_C1404 @default.
- NCIT_C84837 subClassOf NCIT_C163758 @default.
- NCIT_C84837 subClassOf NCIT_C1742 @default.
- NCIT_C84837 subClassOf NCIT_C1908 @default.
- NCIT_C84837 subClassOf NCIT_C1909 @default.
- NCIT_C84837 subClassOf NCIT_C2152 @default.
- NCIT_C84837 subClassOf NCIT_C2189 @default.
- NCIT_C84837 subClassOf NCIT_C274 @default.
- NCIT_C84837 subClassOf NCIT_C471 @default.
- NCIT_C84837 subClassOf NCIT_C84837 @default.