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- NCIT_C84846 IAO_0000115 "A small-molecule pan-Aurora kinase inhibitor with potential antineoplastic activity. Aurora kinase inhibitor TTP607 selectively binds to and inhibits Aurora kinases A, B and C, which may result in the disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cellular division and proliferation in Aurora kinase-overexpressing tumor cells. Aurora kinases A, B and C, are serine/threonine kinases that play essential roles in mitotic checkpoint control and are overexpressed by a wide variety of tumor cell types." @default.
- NCIT_C84846 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84846 NCIT_NHC0 "C84846" @default.
- NCIT_C84846 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84846 NCIT_P108 "Aurora Kinase Inhibitor TTP607" @default.
- NCIT_C84846 NCIT_P208 "CL412399" @default.
- NCIT_C84846 NCIT_P322 "GDC" @default.
- NCIT_C84846 NCIT_P329 "650689" @default.
- NCIT_C84846 NCIT_P330 "650689" @default.
- NCIT_C84846 NCIT_P375 "Aurora Kinase Inhibitor TTP607" @default.
- NCIT_C84846 NCIT_P399 "650689" @default.
- NCIT_C84846 NCIT_R146 NCIT_C16554 @default.
- NCIT_C84846 NCIT_R146 NCIT_C16984 @default.
- NCIT_C84846 NCIT_R146 NCIT_C17018 @default.
- NCIT_C84846 NCIT_R146 NCIT_C17021 @default.
- NCIT_C84846 NCIT_R146 NCIT_C17210 @default.
- NCIT_C84846 NCIT_R146 NCIT_C17325 @default.
- NCIT_C84846 NCIT_R146 NCIT_C20027 @default.
- NCIT_C84846 NCIT_R146 NCIT_C26548 @default.
- NCIT_C84846 NCIT_R146 NCIT_C30006 @default.
- NCIT_C84846 normalizedInformationContent "100" @default.
- NCIT_C84846 referenceCount "1" @default.
- NCIT_C84846 hasExactSynonym "Aurora Kinase Inhibitor TTP607" @default.
- NCIT_C84846 hasExactSynonym "TTP607" @default.
- NCIT_C84846 inSubset NCIT_C128784 @default.
- NCIT_C84846 inSubset NCIT_C157711 @default.
- NCIT_C84846 inSubset NCIT_C157712 @default.
- NCIT_C84846 inSubset NCIT_C176424 @default.
- NCIT_C84846 inSubset NCIT_C177537 @default.
- NCIT_C84846 type Class @default.
- NCIT_C84846 isDefinedBy ncit.owl @default.
- NCIT_C84846 label "Aurora Kinase Inhibitor TTP607" @default.
- NCIT_C84846 subClassOf NCIT_C129824 @default.
- NCIT_C84846 subClassOf NCIT_C129825 @default.
- NCIT_C84846 subClassOf NCIT_C1404 @default.
- NCIT_C84846 subClassOf NCIT_C1908 @default.
- NCIT_C84846 subClassOf NCIT_C1909 @default.
- NCIT_C84846 subClassOf NCIT_C2189 @default.
- NCIT_C84846 subClassOf NCIT_C274 @default.
- NCIT_C84846 subClassOf NCIT_C471 @default.
- NCIT_C84846 subClassOf NCIT_C61074 @default.
- NCIT_C84846 subClassOf NCIT_C62556 @default.
- NCIT_C84846 subClassOf NCIT_C84846 @default.