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- NCIT_C84855 IAO_0000115 "An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody, directed against the extracellular domain of the human CD70 molecule, conjugated to a prodrug of a CC-1065 (rachelmycin) analogue via a stable peptide-based linker, with potential antineoplastic activity. The anti-CD70 antibody moiety of the anti-CD70 antibody-drug conjugate MDX-1203 selectively binds to the extracellular domain of CD70 on tumor cell surfaces. Upon internalization, the prodrug moiety is released and activated and binds to double-stranded B-DNA within the minor groove, thereby alkylating the -3 position of adenine, which may result in the inhibition of cellular proliferation of tumor cells that overexpress CD70. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells. The antitumor antibiotic CC-1065, a DNA minor-groove-binding alkylating agent, was originally isolated from the bacterium Streptomyces zelensis." @default.
- NCIT_C84855 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84855 NCIT_A7 NCIT_C104079 @default.
- NCIT_C84855 NCIT_NHC0 "C84855" @default.
- NCIT_C84855 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84855 NCIT_P107 "Anti-CD70 Antibody-Drug Conjugate MDX-1203" @default.
- NCIT_C84855 NCIT_P108 "Anti-CD70 Antibody-Drug Conjugate MDX-1203" @default.
- NCIT_C84855 NCIT_P207 "C2827532" @default.
- NCIT_C84855 NCIT_P322 "CTRP" @default.
- NCIT_C84855 NCIT_P322 "GDC" @default.
- NCIT_C84855 NCIT_P329 "651385" @default.
- NCIT_C84855 NCIT_P330 "651385" @default.
- NCIT_C84855 NCIT_P375 "Anti-CD70 Antibody-Drug Conjugate MDX-1203" @default.
- NCIT_C84855 NCIT_P399 "651385" @default.
- NCIT_C84855 normalizedInformationContent "100" @default.
- NCIT_C84855 referenceCount "1" @default.
- NCIT_C84855 hasExactSynonym "Anti-CD70 ADC MDX-1203" @default.
- NCIT_C84855 hasExactSynonym "Anti-CD70 Antibody-Drug Conjugate MDX-1203" @default.
- NCIT_C84855 hasExactSynonym "MDX-1203" @default.
- NCIT_C84855 inSubset NCIT_C116977 @default.
- NCIT_C84855 inSubset NCIT_C116978 @default.
- NCIT_C84855 inSubset NCIT_C128784 @default.
- NCIT_C84855 inSubset NCIT_C157711 @default.
- NCIT_C84855 inSubset NCIT_C157712 @default.
- NCIT_C84855 inSubset NCIT_C176424 @default.
- NCIT_C84855 inSubset NCIT_C177537 @default.
- NCIT_C84855 type Class @default.
- NCIT_C84855 isDefinedBy ncit.owl @default.
- NCIT_C84855 label "Anti-CD70 Antibody-Drug Conjugate MDX-1203" @default.
- NCIT_C84855 subClassOf NCIT_C129821 @default.
- NCIT_C84855 subClassOf NCIT_C129823 @default.
- NCIT_C84855 subClassOf NCIT_C1512 @default.
- NCIT_C84855 subClassOf NCIT_C163758 @default.
- NCIT_C84855 subClassOf NCIT_C1908 @default.
- NCIT_C84855 subClassOf NCIT_C1909 @default.
- NCIT_C84855 subClassOf NCIT_C200042 @default.
- NCIT_C84855 subClassOf NCIT_C201550 @default.
- NCIT_C84855 subClassOf NCIT_C274 @default.
- NCIT_C84855 subClassOf NCIT_C307 @default.
- NCIT_C84855 subClassOf NCIT_C308 @default.
- NCIT_C84855 subClassOf NCIT_C84855 @default.