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- NCIT_C84856 IAO_0000115 "An orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity. Resminostat binds to and inhibits HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, inhibition of the transcription of tumor suppressor genes, inhibition of tumor cell division and the induction of tumor cell apoptosis. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins." @default.
- NCIT_C84856 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84856 NCIT_NHC0 "C84856" @default.
- NCIT_C84856 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84856 NCIT_P108 "Resminostat" @default.
- NCIT_C84856 NCIT_P207 "C2935131" @default.
- NCIT_C84856 NCIT_P210 "864814-88-0" @default.
- NCIT_C84856 NCIT_P319 "1578EUB98L" @default.
- NCIT_C84856 NCIT_P322 "FDA" @default.
- NCIT_C84856 NCIT_P322 "GDC" @default.
- NCIT_C84856 NCIT_P329 "651465" @default.
- NCIT_C84856 NCIT_P330 "651465" @default.
- NCIT_C84856 NCIT_P350 "C16H19N3O4S" @default.
- NCIT_C84856 NCIT_P375 "Resminostat" @default.
- NCIT_C84856 NCIT_P399 "651465" @default.
- NCIT_C84856 normalizedInformationContent "100" @default.
- NCIT_C84856 referenceCount "1" @default.
- NCIT_C84856 hasExactSynonym "4SC-201" @default.
- NCIT_C84856 hasExactSynonym "RESMINOSTAT" @default.
- NCIT_C84856 hasExactSynonym "Resminostat" @default.
- NCIT_C84856 inSubset NCIT_C128784 @default.
- NCIT_C84856 inSubset NCIT_C157711 @default.
- NCIT_C84856 inSubset NCIT_C157712 @default.
- NCIT_C84856 inSubset NCIT_C176424 @default.
- NCIT_C84856 inSubset NCIT_C177537 @default.
- NCIT_C84856 inSubset NCIT_C63923 @default.
- NCIT_C84856 type Class @default.
- NCIT_C84856 isDefinedBy ncit.owl @default.
- NCIT_C84856 label "Resminostat" @default.
- NCIT_C84856 subClassOf NCIT_C163758 @default.
- NCIT_C84856 subClassOf NCIT_C1908 @default.
- NCIT_C84856 subClassOf NCIT_C1909 @default.
- NCIT_C84856 subClassOf NCIT_C1946 @default.
- NCIT_C84856 subClassOf NCIT_C274 @default.
- NCIT_C84856 subClassOf NCIT_C471 @default.
- NCIT_C84856 subClassOf NCIT_C84856 @default.