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- NCIT_C84858 IAO_0000115 "An orally bioavailable, non-ATP-competitive, allosteric, small-molecule inhibitor of mitogen-activated protein kinase kinase (MAP2K; MAPK/ERK kinase; MEK) 1 and MEK2, with potential antineoplastic activity. Upon oral administration, MEK inhibitor REC-4881 selectively binds to and inhibits the activity of MEK1/2. This prevents the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types." @default.
- NCIT_C84858 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84858 NCIT_A7 NCIT_C106633 @default.
- NCIT_C84858 NCIT_A7 NCIT_C17808 @default.
- NCIT_C84858 NCIT_NHC0 "C84858" @default.
- NCIT_C84858 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84858 NCIT_P107 "MEK Inhibitor REC-4881" @default.
- NCIT_C84858 NCIT_P108 "MEK Inhibitor REC-4881" @default.
- NCIT_C84858 NCIT_P207 "C2827535" @default.
- NCIT_C84858 NCIT_P210 "1035555-63-5" @default.
- NCIT_C84858 NCIT_P319 "5J61HSP0QJ" @default.
- NCIT_C84858 NCIT_P322 "CTRP" @default.
- NCIT_C84858 NCIT_P322 "FDA" @default.
- NCIT_C84858 NCIT_P322 "GDC" @default.
- NCIT_C84858 NCIT_P329 "651550" @default.
- NCIT_C84858 NCIT_P330 "651550" @default.
- NCIT_C84858 NCIT_P375 "MEK Inhibitor TAK-733" @default.
- NCIT_C84858 NCIT_P399 "651550" @default.
- NCIT_C84858 normalizedInformationContent "100" @default.
- NCIT_C84858 referenceCount "1" @default.
- NCIT_C84858 hasExactSynonym "MEK Inhibitor REC-4881" @default.
- NCIT_C84858 hasExactSynonym "REC 4881" @default.
- NCIT_C84858 hasExactSynonym "REC-4881" @default.
- NCIT_C84858 hasExactSynonym "REC4881" @default.
- NCIT_C84858 hasExactSynonym "TAK-733" @default.
- NCIT_C84858 inSubset NCIT_C116977 @default.
- NCIT_C84858 inSubset NCIT_C116978 @default.
- NCIT_C84858 inSubset NCIT_C128784 @default.
- NCIT_C84858 inSubset NCIT_C157711 @default.
- NCIT_C84858 inSubset NCIT_C157712 @default.
- NCIT_C84858 inSubset NCIT_C176424 @default.
- NCIT_C84858 inSubset NCIT_C177537 @default.
- NCIT_C84858 inSubset NCIT_C63923 @default.
- NCIT_C84858 type Class @default.
- NCIT_C84858 isDefinedBy ncit.owl @default.
- NCIT_C84858 label "MEK Inhibitor REC-4881" @default.
- NCIT_C84858 subClassOf NCIT_C129824 @default.
- NCIT_C84858 subClassOf NCIT_C129825 @default.
- NCIT_C84858 subClassOf NCIT_C1404 @default.
- NCIT_C84858 subClassOf NCIT_C163758 @default.
- NCIT_C84858 subClassOf NCIT_C1908 @default.
- NCIT_C84858 subClassOf NCIT_C1909 @default.
- NCIT_C84858 subClassOf NCIT_C2189 @default.
- NCIT_C84858 subClassOf NCIT_C274 @default.
- NCIT_C84858 subClassOf NCIT_C471 @default.
- NCIT_C84858 subClassOf NCIT_C69145 @default.
- NCIT_C84858 subClassOf NCIT_C84858 @default.