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- NCIT_C84864 IAO_0000115 "An orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types." @default.
- NCIT_C84864 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84864 NCIT_A7 NCIT_C106633 @default.
- NCIT_C84864 NCIT_A7 NCIT_C17808 @default.
- NCIT_C84864 NCIT_NHC0 "C84864" @default.
- NCIT_C84864 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84864 NCIT_P107 "Pimasertib" @default.
- NCIT_C84864 NCIT_P108 "Pimasertib" @default.
- NCIT_C84864 NCIT_P207 "C2830124" @default.
- NCIT_C84864 NCIT_P210 "1236699-92-5" @default.
- NCIT_C84864 NCIT_P319 "6ON9RK82AL" @default.
- NCIT_C84864 NCIT_P322 "CTRP" @default.
- NCIT_C84864 NCIT_P322 "FDA" @default.
- NCIT_C84864 NCIT_P322 "GDC" @default.
- NCIT_C84864 NCIT_P329 "653634" @default.
- NCIT_C84864 NCIT_P330 "653634" @default.
- NCIT_C84864 NCIT_P350 "C15H15FIN3O3" @default.
- NCIT_C84864 NCIT_P375 "Pimasertib" @default.
- NCIT_C84864 NCIT_P399 "653634" @default.
- NCIT_C84864 normalizedInformationContent "100" @default.
- NCIT_C84864 referenceCount "1" @default.
- NCIT_C84864 hasExactSynonym "AS703026" @default.
- NCIT_C84864 hasExactSynonym "EMD 1036239" @default.
- NCIT_C84864 hasExactSynonym "MSC1936369" @default.
- NCIT_C84864 hasExactSynonym "N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4- iodophenyl)amino]isonicotinamide Hydrochloride" @default.
- NCIT_C84864 hasExactSynonym "PIMASERTIB" @default.
- NCIT_C84864 hasExactSynonym "Pimasertib" @default.
- NCIT_C84864 inSubset NCIT_C116977 @default.
- NCIT_C84864 inSubset NCIT_C116978 @default.
- NCIT_C84864 inSubset NCIT_C128784 @default.
- NCIT_C84864 inSubset NCIT_C157711 @default.
- NCIT_C84864 inSubset NCIT_C157712 @default.
- NCIT_C84864 inSubset NCIT_C176424 @default.
- NCIT_C84864 inSubset NCIT_C177537 @default.
- NCIT_C84864 inSubset NCIT_C63923 @default.
- NCIT_C84864 type Class @default.
- NCIT_C84864 isDefinedBy ncit.owl @default.
- NCIT_C84864 label "Pimasertib" @default.
- NCIT_C84864 subClassOf NCIT_C129824 @default.
- NCIT_C84864 subClassOf NCIT_C129825 @default.
- NCIT_C84864 subClassOf NCIT_C1404 @default.
- NCIT_C84864 subClassOf NCIT_C163758 @default.
- NCIT_C84864 subClassOf NCIT_C1908 @default.
- NCIT_C84864 subClassOf NCIT_C1909 @default.
- NCIT_C84864 subClassOf NCIT_C2189 @default.
- NCIT_C84864 subClassOf NCIT_C274 @default.
- NCIT_C84864 subClassOf NCIT_C471 @default.
- NCIT_C84864 subClassOf NCIT_C69145 @default.
- NCIT_C84864 subClassOf NCIT_C84864 @default.