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- NCIT_C84865 IAO_0000115 "An orally available inhibitor of mitogen-activated protein kinase kinase 1 and 2 (MEK1/2) with potential antineoplastic activity. Binimetinib, noncompetitive with ATP, binds to and inhibits the activity of MEK1/2. Inhibition of MEK1/2 prevents the activation of MEK1/2 dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling. This may eventually lead to an inhibition of tumor cell proliferation and an inhibition in production of various inflammatory cytokines including interleukin-1, -6 and tumor necrosis factor. MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types." @default.
- NCIT_C84865 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84865 NCIT_A7 NCIT_C105947 @default.
- NCIT_C84865 NCIT_NHC0 "C84865" @default.
- NCIT_C84865 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84865 NCIT_P107 "Binimetinib" @default.
- NCIT_C84865 NCIT_P108 "Binimetinib" @default.
- NCIT_C84865 NCIT_P207 "C2830125" @default.
- NCIT_C84865 NCIT_P210 "606143-89-9" @default.
- NCIT_C84865 NCIT_P302 "in combination with encorafenib, for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation" @default.
- NCIT_C84865 NCIT_P319 "181R97MR71" @default.
- NCIT_C84865 NCIT_P322 "CTRP" @default.
- NCIT_C84865 NCIT_P322 "FDA" @default.
- NCIT_C84865 NCIT_P322 "GDC" @default.
- NCIT_C84865 NCIT_P329 "653635" @default.
- NCIT_C84865 NCIT_P330 "653635" @default.
- NCIT_C84865 NCIT_P375 "Binimetinib" @default.
- NCIT_C84865 NCIT_P399 "653635" @default.
- NCIT_C84865 normalizedInformationContent "89.350088392419622" @default.
- NCIT_C84865 referenceCount "5" @default.
- NCIT_C84865 hasExactSynonym "ARRY-162" @default.
- NCIT_C84865 hasExactSynonym "ARRY-438162" @default.
- NCIT_C84865 hasExactSynonym "BINIMETINIB" @default.
- NCIT_C84865 hasExactSynonym "Binimetinib" @default.
- NCIT_C84865 hasExactSynonym "MEK162" @default.
- NCIT_C84865 hasExactSynonym "Mektovi" @default.
- NCIT_C84865 inSubset NCIT_C116977 @default.
- NCIT_C84865 inSubset NCIT_C116978 @default.
- NCIT_C84865 inSubset NCIT_C128784 @default.
- NCIT_C84865 inSubset NCIT_C157711 @default.
- NCIT_C84865 inSubset NCIT_C157712 @default.
- NCIT_C84865 inSubset NCIT_C176424 @default.
- NCIT_C84865 inSubset NCIT_C177537 @default.
- NCIT_C84865 inSubset NCIT_C63923 @default.
- NCIT_C84865 type Class @default.
- NCIT_C84865 isDefinedBy ncit.owl @default.
- NCIT_C84865 label "Binimetinib" @default.
- NCIT_C84865 subClassOf NCIT_C129824 @default.
- NCIT_C84865 subClassOf NCIT_C129825 @default.
- NCIT_C84865 subClassOf NCIT_C1404 @default.
- NCIT_C84865 subClassOf NCIT_C163758 @default.
- NCIT_C84865 subClassOf NCIT_C1908 @default.
- NCIT_C84865 subClassOf NCIT_C1909 @default.
- NCIT_C84865 subClassOf NCIT_C2189 @default.
- NCIT_C84865 subClassOf NCIT_C274 @default.
- NCIT_C84865 subClassOf NCIT_C471 @default.
- NCIT_C84865 subClassOf NCIT_C69145 @default.
- NCIT_C84865 subClassOf NCIT_C84865 @default.