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- NCIT_C84866 IAO_0000115 "An orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor and 3) by decreasing overall androgen receptor levels in prostate cancer tumors, all of which may result in a decrease in androgen-dependent growth signaling. Localized to the endoplasmic reticulum (ER), the cytochrome P450 enzyme CYP17 (P450C17 or CYP17A1) exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens." @default.
- NCIT_C84866 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84866 NCIT_A7 NCIT_C17063 @default.
- NCIT_C84866 NCIT_A7 NCIT_C40068 @default.
- NCIT_C84866 NCIT_NHC0 "C84866" @default.
- NCIT_C84866 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84866 NCIT_P107 "Galeterone" @default.
- NCIT_C84866 NCIT_P108 "Galeterone" @default.
- NCIT_C84866 NCIT_P207 "C3490719" @default.
- NCIT_C84866 NCIT_P210 "851983-85-2" @default.
- NCIT_C84866 NCIT_P319 "WA33E149SW" @default.
- NCIT_C84866 NCIT_P322 "CTRP" @default.
- NCIT_C84866 NCIT_P322 "FDA" @default.
- NCIT_C84866 NCIT_P322 "GDC" @default.
- NCIT_C84866 NCIT_P329 "653977" @default.
- NCIT_C84866 NCIT_P330 "653977" @default.
- NCIT_C84866 NCIT_P350 "C26H32N2O" @default.
- NCIT_C84866 NCIT_P375 "Galeterone" @default.
- NCIT_C84866 NCIT_P399 "653977" @default.
- NCIT_C84866 normalizedInformationContent "100" @default.
- NCIT_C84866 referenceCount "1" @default.
- NCIT_C84866 hasExactSynonym "Androsta-5,16-dien-3-ol, 17-(1h-benzimidazol-1-yl)-, (3beta)-" @default.
- NCIT_C84866 hasExactSynonym "GALETERONE" @default.
- NCIT_C84866 hasExactSynonym "Galeterone" @default.
- NCIT_C84866 hasExactSynonym "Specific Androgen Receptor Modulator/CYP17 Lyase Inhibitor TOK-001" @default.
- NCIT_C84866 hasExactSynonym "TOK-001" @default.
- NCIT_C84866 hasExactSynonym "VN/124" @default.
- NCIT_C84866 hasExactSynonym "VN/124-1" @default.
- NCIT_C84866 inSubset NCIT_C116977 @default.
- NCIT_C84866 inSubset NCIT_C116978 @default.
- NCIT_C84866 inSubset NCIT_C128784 @default.
- NCIT_C84866 inSubset NCIT_C157711 @default.
- NCIT_C84866 inSubset NCIT_C157712 @default.
- NCIT_C84866 inSubset NCIT_C176424 @default.
- NCIT_C84866 inSubset NCIT_C177537 @default.
- NCIT_C84866 inSubset NCIT_C63923 @default.
- NCIT_C84866 type Class @default.
- NCIT_C84866 isDefinedBy ncit.owl @default.
- NCIT_C84866 label "Galeterone" @default.
- NCIT_C84866 subClassOf NCIT_C1908 @default.
- NCIT_C84866 subClassOf NCIT_C1909 @default.
- NCIT_C84866 subClassOf NCIT_C471 @default.
- NCIT_C84866 subClassOf NCIT_C84866 @default.