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- NCIT_C84868 IAO_0000115 "A ghrelin peptide analogue with potential anti-cachexia activity. Upon subcutaneous administration, ghrelin peptide analogue binds to and stimulates the G protein-coupled growth hormone secretagogue receptor (GHSR) in the central nervous system (CNS), thereby mimicking the appetite-stimulating and growth hormone-releasing effects of endogenous ghrelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play direct roles in cancer-related loss of appetite. Ghrelin, naturally secreted by gastric endocrine cells, is a 28 amino acid peptide and an endogenous ligand for GHSR." @default.
- NCIT_C84868 NCIT_NHC0 "C84868" @default.
- NCIT_C84868 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C84868 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84868 NCIT_P108 "Ghrelin Peptide Analogue" @default.
- NCIT_C84868 NCIT_P208 "CL412389" @default.
- NCIT_C84868 NCIT_P329 "650024" @default.
- NCIT_C84868 NCIT_P330 "650024" @default.
- NCIT_C84868 NCIT_P399 "650024" @default.
- NCIT_C84868 normalizedInformationContent "89.350088392419622" @default.
- NCIT_C84868 referenceCount "5" @default.
- NCIT_C84868 hasExactSynonym "Ghrelin Peptide Analogue" @default.
- NCIT_C84868 inSubset NCIT_C176424 @default.
- NCIT_C84868 type Class @default.
- NCIT_C84868 isDefinedBy ncit.owl @default.
- NCIT_C84868 label "Ghrelin Peptide Analogue" @default.
- NCIT_C84868 subClassOf NCIT_C147908 @default.
- NCIT_C84868 subClassOf NCIT_C1908 @default.
- NCIT_C84868 subClassOf NCIT_C1909 @default.
- NCIT_C84868 subClassOf NCIT_C1935 @default.
- NCIT_C84868 subClassOf NCIT_C548 @default.
- NCIT_C84868 subClassOf NCIT_C76358 @default.
- NCIT_C84868 subClassOf NCIT_C78281 @default.
- NCIT_C84868 subClassOf NCIT_C84868 @default.