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- NCIT_C84870 IAO_0000115 "An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Uprosertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents." @default.
- NCIT_C84870 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84870 NCIT_A7 NCIT_C41625 @default.
- NCIT_C84870 NCIT_NHC0 "C84870" @default.
- NCIT_C84870 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84870 NCIT_P107 "Uprosertib" @default.
- NCIT_C84870 NCIT_P108 "Uprosertib" @default.
- NCIT_C84870 NCIT_P207 "C2830127" @default.
- NCIT_C84870 NCIT_P210 "1047634-65-0" @default.
- NCIT_C84870 NCIT_P319 "ZXM835LQ5E" @default.
- NCIT_C84870 NCIT_P322 "CTRP" @default.
- NCIT_C84870 NCIT_P322 "FDA" @default.
- NCIT_C84870 NCIT_P322 "GDC" @default.
- NCIT_C84870 NCIT_P329 "648336" @default.
- NCIT_C84870 NCIT_P330 "648336" @default.
- NCIT_C84870 NCIT_P375 "Uprosertib" @default.
- NCIT_C84870 NCIT_P399 "648336" @default.
- NCIT_C84870 normalizedInformationContent "100" @default.
- NCIT_C84870 referenceCount "1" @default.
- NCIT_C84870 hasExactSynonym "2-Furancarboxamide, N-((1S)-2-Amino-1-((3,4-difluorophenyl)methyl)ethyl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-" @default.
- NCIT_C84870 hasExactSynonym "GSK2141795" @default.
- NCIT_C84870 hasExactSynonym "Oral Akt Inhibitor GSK2141795" @default.
- NCIT_C84870 hasExactSynonym "UPROSERTIB" @default.
- NCIT_C84870 hasExactSynonym "Uprosertib" @default.
- NCIT_C84870 inSubset NCIT_C116977 @default.
- NCIT_C84870 inSubset NCIT_C116978 @default.
- NCIT_C84870 inSubset NCIT_C128784 @default.
- NCIT_C84870 inSubset NCIT_C157711 @default.
- NCIT_C84870 inSubset NCIT_C157712 @default.
- NCIT_C84870 inSubset NCIT_C176424 @default.
- NCIT_C84870 inSubset NCIT_C177537 @default.
- NCIT_C84870 inSubset NCIT_C63923 @default.
- NCIT_C84870 type Class @default.
- NCIT_C84870 isDefinedBy ncit.owl @default.
- NCIT_C84870 label "Uprosertib" @default.
- NCIT_C84870 subClassOf NCIT_C129824 @default.
- NCIT_C84870 subClassOf NCIT_C129825 @default.
- NCIT_C84870 subClassOf NCIT_C1404 @default.
- NCIT_C84870 subClassOf NCIT_C155764 @default.
- NCIT_C84870 subClassOf NCIT_C1742 @default.
- NCIT_C84870 subClassOf NCIT_C1908 @default.
- NCIT_C84870 subClassOf NCIT_C1909 @default.
- NCIT_C84870 subClassOf NCIT_C2189 @default.
- NCIT_C84870 subClassOf NCIT_C274 @default.
- NCIT_C84870 subClassOf NCIT_C471 @default.
- NCIT_C84870 subClassOf NCIT_C61074 @default.
- NCIT_C84870 subClassOf NCIT_C84870 @default.