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- NCIT_C84871 IAO_0000115 "An orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis." @default.
- NCIT_C84871 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84871 NCIT_A7 NCIT_C17072 @default.
- NCIT_C84871 NCIT_A7 NCIT_C17531 @default.
- NCIT_C84871 NCIT_NHC0 "C84871" @default.
- NCIT_C84871 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84871 NCIT_P107 "IGF-1R/IR Inhibitor KW-2450" @default.
- NCIT_C84871 NCIT_P108 "IGF-1R/IR Inhibitor KW-2450" @default.
- NCIT_C84871 NCIT_P208 "CL412997" @default.
- NCIT_C84871 NCIT_P210 "1360433-93-7" @default.
- NCIT_C84871 NCIT_P319 "2TRH1EX32K" @default.
- NCIT_C84871 NCIT_P322 "CTRP" @default.
- NCIT_C84871 NCIT_P322 "FDA" @default.
- NCIT_C84871 NCIT_P322 "GDC" @default.
- NCIT_C84871 NCIT_P329 "648543" @default.
- NCIT_C84871 NCIT_P330 "648543" @default.
- NCIT_C84871 NCIT_P375 "IGF-1R/IR Inhibitor KW-2450" @default.
- NCIT_C84871 NCIT_P399 "648543" @default.
- NCIT_C84871 normalizedInformationContent "100" @default.
- NCIT_C84871 referenceCount "1" @default.
- NCIT_C84871 hasExactSynonym "IGF-1R/IR Inhibitor KW-2450" @default.
- NCIT_C84871 hasExactSynonym "KW-2450" @default.
- NCIT_C84871 inSubset NCIT_C116977 @default.
- NCIT_C84871 inSubset NCIT_C116978 @default.
- NCIT_C84871 inSubset NCIT_C128784 @default.
- NCIT_C84871 inSubset NCIT_C157711 @default.
- NCIT_C84871 inSubset NCIT_C157712 @default.
- NCIT_C84871 inSubset NCIT_C176424 @default.
- NCIT_C84871 inSubset NCIT_C177537 @default.
- NCIT_C84871 inSubset NCIT_C63923 @default.
- NCIT_C84871 type Class @default.
- NCIT_C84871 isDefinedBy ncit.owl @default.
- NCIT_C84871 label "IGF-1R/IR Inhibitor KW-2450" @default.
- NCIT_C84871 subClassOf NCIT_C129824 @default.
- NCIT_C84871 subClassOf NCIT_C129825 @default.
- NCIT_C84871 subClassOf NCIT_C1404 @default.
- NCIT_C84871 subClassOf NCIT_C1908 @default.
- NCIT_C84871 subClassOf NCIT_C1909 @default.
- NCIT_C84871 subClassOf NCIT_C1967 @default.
- NCIT_C84871 subClassOf NCIT_C2189 @default.
- NCIT_C84871 subClassOf NCIT_C274 @default.
- NCIT_C84871 subClassOf NCIT_C471 @default.
- NCIT_C84871 subClassOf NCIT_C84871 @default.