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- NCIT_C84872 IAO_0000115 "A non-small cell lung cancer (NSCLC) vaccine containing modified mRNAs encoding cancer-testis antigen NY-ESO-1, melanoma-associated antigens C1 (MAGE-C1/CT7) and C2 (MAGE-C2/CT10), survivin, and the oncofetal antigen 5T4 with potential antitumor and immunomodulatory activities. Upon subcutaneous administration, non-small cell lung cancer mRNA-derived vaccine CV9201 may stimulate the immune system to mount a cytotoxic, antigen-specific T lymphocyte response (CTL) against NSCLC cells. The modified mRNAs in this vaccine are taken up by cells after injection and exhibit enhanced translational potency. The five tumor-associated antigens (TAAs) encoded by these mRNAs are frequently expressed by NSCLC cells." @default.
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- NCIT_C84872 NCIT_NHC0 "C84872" @default.
- NCIT_C84872 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C84872 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84872 NCIT_P108 "Non-Small Cell Lung Cancer mRNA-Derived Vaccine CV9201" @default.
- NCIT_C84872 NCIT_P208 "CL412376" @default.
- NCIT_C84872 NCIT_P322 "GDC" @default.
- NCIT_C84872 NCIT_P329 "648549" @default.
- NCIT_C84872 NCIT_P330 "648549" @default.
- NCIT_C84872 NCIT_P375 "Non-Small Cell Lung Cancer mRNA-Derived Vaccine CV9201" @default.
- NCIT_C84872 NCIT_P399 "648549" @default.
- NCIT_C84872 normalizedInformationContent "100" @default.
- NCIT_C84872 referenceCount "1" @default.
- NCIT_C84872 hasExactSynonym "CV9201" @default.
- NCIT_C84872 hasExactSynonym "Non-Small Cell Lung Cancer mRNA-Derived Vaccine CV9201" @default.
- NCIT_C84872 inSubset NCIT_C128784 @default.
- NCIT_C84872 inSubset NCIT_C157711 @default.
- NCIT_C84872 inSubset NCIT_C157712 @default.
- NCIT_C84872 inSubset NCIT_C176424 @default.
- NCIT_C84872 inSubset NCIT_C177537 @default.
- NCIT_C84872 type Class @default.
- NCIT_C84872 isDefinedBy ncit.owl @default.
- NCIT_C84872 label "Non-Small Cell Lung Cancer mRNA-Derived Vaccine CV9201" @default.
- NCIT_C84872 subClassOf NCIT_C129820 @default.
- NCIT_C84872 subClassOf NCIT_C1663 @default.
- NCIT_C84872 subClassOf NCIT_C172787 @default.
- NCIT_C84872 subClassOf NCIT_C181141 @default.
- NCIT_C84872 subClassOf NCIT_C1908 @default.
- NCIT_C84872 subClassOf NCIT_C1909 @default.
- NCIT_C84872 subClassOf NCIT_C274 @default.
- NCIT_C84872 subClassOf NCIT_C307 @default.
- NCIT_C84872 subClassOf NCIT_C308 @default.
- NCIT_C84872 subClassOf NCIT_C84872 @default.
- NCIT_C84872 subClassOf NCIT_C923 @default.