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- NCIT_C84874 IAO_0000115 "A tablet preparation formulated for vaginal administration containing a micronized synthetic form of the endogenous steroid hormone progesterone with progesterone activity. Upon vaginal insertion, progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogen by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy." @default.
- NCIT_C84874 NCIT_NHC0 "C84874" @default.
- NCIT_C84874 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84874 NCIT_P108 "Progesterone Vaginal Insert" @default.
- NCIT_C84874 NCIT_P207 "C1961966" @default.
- NCIT_C84874 NCIT_P329 "648749" @default.
- NCIT_C84874 NCIT_P330 "648749" @default.
- NCIT_C84874 NCIT_P399 "648749" @default.
- NCIT_C84874 normalizedInformationContent "100" @default.
- NCIT_C84874 referenceCount "1" @default.
- NCIT_C84874 hasExactSynonym "Endometrin" @default.
- NCIT_C84874 hasExactSynonym "Progesterone Vaginal Insert" @default.
- NCIT_C84874 inSubset NCIT_C176424 @default.
- NCIT_C84874 type Class @default.
- NCIT_C84874 isDefinedBy ncit.owl @default.
- NCIT_C84874 label "Progesterone Vaginal Insert" @default.
- NCIT_C84874 subClassOf NCIT_C147908 @default.
- NCIT_C84874 subClassOf NCIT_C1636 @default.
- NCIT_C84874 subClassOf NCIT_C1908 @default.
- NCIT_C84874 subClassOf NCIT_C1909 @default.
- NCIT_C84874 subClassOf NCIT_C548 @default.
- NCIT_C84874 subClassOf NCIT_C776 @default.
- NCIT_C84874 subClassOf NCIT_C84874 @default.