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- NCIT_C84875 IAO_0000115 "An orally bioavailable tablet formulation containing the semisynthetic estrogen estradiol in combination with the acetate form of the synthetic progestin norethindrone, with estrogenic and progesteronic activities. Estradiol binds to and activates intracellular estrogen receptors found in the reproductive tract and other estrogen-responsive tissues. The activated complex enters the nucleus, binds to the estrogen response elements on DNA, and activates the transcription of genes involved in the maintenance of the female reproductive system and secondary sexual characteristics, the proliferation of the endometrium, and bone metabolism. Norethindrone binds to the intracellular progesterone receptors in the reproductive system and the activated ligand/receptor complex interacts with specific DNA response elements, resulting in an alteration in protein synthesis; inhibition of luteinizing hormone (LH) and follicle stimulating hormone (FSH) release; inhibition of ovulation; an increase in cervical mucus production; and induction of the secretory phase of the endometrial cycle. Administration of estradiol/norethindrone acetate may abrogate vasomotor symptoms associated with menopause and prevent bone loss associated with the postmenopause. Because chronic estrogen stimulation unopposed by progesterone may increase the risk of the endometrial carcinoma, administration of a combination estrogen-progestin in postmenopause may reduce the risk for women who require estrogen replacement therapy." @default.
- NCIT_C84875 NCIT_NHC0 "C84875" @default.
- NCIT_C84875 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84875 NCIT_P108 "Estradiol/Norethindrone Acetate Tablet" @default.
- NCIT_C84875 NCIT_P208 "CL938205" @default.
- NCIT_C84875 NCIT_P329 "648750" @default.
- NCIT_C84875 NCIT_P330 "648750" @default.
- NCIT_C84875 NCIT_P399 "648750" @default.
- NCIT_C84875 normalizedInformationContent "100" @default.
- NCIT_C84875 referenceCount "1" @default.
- NCIT_C84875 hasExactSynonym "Activella" @default.
- NCIT_C84875 hasExactSynonym "Estradiol/Norethindrone Acetate Tablet" @default.
- NCIT_C84875 inSubset NCIT_C176424 @default.
- NCIT_C84875 type Class @default.
- NCIT_C84875 isDefinedBy ncit.owl @default.
- NCIT_C84875 label "Estradiol/Norethindrone Acetate Tablet" @default.
- NCIT_C84875 subClassOf NCIT_C1908 @default.
- NCIT_C84875 subClassOf NCIT_C1909 @default.
- NCIT_C84875 subClassOf NCIT_C29629 @default.
- NCIT_C84875 subClassOf NCIT_C29640 @default.
- NCIT_C84875 subClassOf NCIT_C84875 @default.