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- NCIT_C84880 IAO_0000115 "A small-molecule prodrug of CEP-8983, a novel 4-methoxy-carbazole inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration and conversion from CEP-9722, CEP-8983 selectively binds to PARP 1 and 2, preventing repair of damaged DNA via base excision repair (BER). This agent enhances the accumulation of DNA strand breaks and promotes genomic instability and apoptosis. CEP-8983 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand breaks in DNA." @default.
- NCIT_C84880 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84880 NCIT_A7 NCIT_C104720 @default.
- NCIT_C84880 NCIT_A7 NCIT_C48215 @default.
- NCIT_C84880 NCIT_NHC0 "C84880" @default.
- NCIT_C84880 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84880 NCIT_P107 "PARP Inhibitor CEP-9722" @default.
- NCIT_C84880 NCIT_P108 "PARP Inhibitor CEP-9722" @default.
- NCIT_C84880 NCIT_P207 "C2827554" @default.
- NCIT_C84880 NCIT_P210 "916574-83-9" @default.
- NCIT_C84880 NCIT_P319 "B68083E4YG" @default.
- NCIT_C84880 NCIT_P322 "CTRP" @default.
- NCIT_C84880 NCIT_P322 "FDA" @default.
- NCIT_C84880 NCIT_P322 "GDC" @default.
- NCIT_C84880 NCIT_P329 "649505" @default.
- NCIT_C84880 NCIT_P330 "649505" @default.
- NCIT_C84880 NCIT_P375 "PARP Inhibitor CEP-9722" @default.
- NCIT_C84880 NCIT_P399 "649505" @default.
- NCIT_C84880 NCIT_R146 NCIT_C104101 @default.
- NCIT_C84880 NCIT_R146 NCIT_C16554 @default.
- NCIT_C84880 NCIT_R146 NCIT_C17021 @default.
- NCIT_C84880 NCIT_R146 NCIT_C17210 @default.
- NCIT_C84880 NCIT_R146 NCIT_C17434 @default.
- NCIT_C84880 NCIT_R146 NCIT_C20027 @default.
- NCIT_C84880 NCIT_R146 NCIT_C21170 @default.
- NCIT_C84880 NCIT_R146 NCIT_C26548 @default.
- NCIT_C84880 NCIT_R146 NCIT_C48215 @default.
- NCIT_C84880 normalizedInformationContent "100" @default.
- NCIT_C84880 referenceCount "1" @default.
- NCIT_C84880 hasExactSynonym "CEP-9722" @default.
- NCIT_C84880 hasExactSynonym "PARP Inhibitor CEP-9722" @default.
- NCIT_C84880 inSubset NCIT_C116977 @default.
- NCIT_C84880 inSubset NCIT_C116978 @default.
- NCIT_C84880 inSubset NCIT_C128784 @default.
- NCIT_C84880 inSubset NCIT_C157711 @default.
- NCIT_C84880 inSubset NCIT_C157712 @default.
- NCIT_C84880 inSubset NCIT_C176424 @default.
- NCIT_C84880 inSubset NCIT_C177537 @default.
- NCIT_C84880 inSubset NCIT_C63923 @default.
- NCIT_C84880 type Class @default.
- NCIT_C84880 isDefinedBy ncit.owl @default.
- NCIT_C84880 label "PARP Inhibitor CEP-9722" @default.
- NCIT_C84880 subClassOf NCIT_C163758 @default.
- NCIT_C84880 subClassOf NCIT_C1908 @default.
- NCIT_C84880 subClassOf NCIT_C1909 @default.
- NCIT_C84880 subClassOf NCIT_C274 @default.
- NCIT_C84880 subClassOf NCIT_C471 @default.
- NCIT_C84880 subClassOf NCIT_C62554 @default.
- NCIT_C84880 subClassOf NCIT_C84880 @default.