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- NCIT_C850 IAO_0000115 "A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)" @default.
- NCIT_C850 NCIT_A32 NCIT_C1909 @default.
- NCIT_C850 NCIT_A7 NCIT_C95469 @default.
- NCIT_C850 NCIT_NHC0 "C850" @default.
- NCIT_C850 NCIT_P106 "Organic Chemical" @default.
- NCIT_C850 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C850 NCIT_P107 "Sulindac" @default.
- NCIT_C850 NCIT_P108 "Sulindac" @default.
- NCIT_C850 NCIT_P207 "C0038792" @default.
- NCIT_C850 NCIT_P210 "38194-50-2" @default.
- NCIT_C850 NCIT_P302 "Arthritis; inflammatory conditions" @default.
- NCIT_C850 NCIT_P319 "184SNS8VUH" @default.
- NCIT_C850 NCIT_P322 "CTRP" @default.
- NCIT_C850 NCIT_P322 "FDA" @default.
- NCIT_C850 NCIT_P322 "GDC" @default.
- NCIT_C850 NCIT_P325 "A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer." @default.
- NCIT_C850 NCIT_P329 "41538" @default.
- NCIT_C850 NCIT_P330 "41538" @default.
- NCIT_C850 NCIT_P350 "C20H17FO3S" @default.
- NCIT_C850 NCIT_P366 "Sulindac" @default.
- NCIT_C850 NCIT_P368 "CHEBI:9352" @default.
- NCIT_C850 NCIT_P375 "Sulindac" @default.
- NCIT_C850 NCIT_P399 "41538" @default.
- NCIT_C850 normalizedInformationContent "88.143637090998837" @default.
- NCIT_C850 referenceCount "6" @default.
- NCIT_C850 hasExactSynonym "(Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid" @default.
- NCIT_C850 hasExactSynonym "Aflodac" @default.
- NCIT_C850 hasExactSynonym "Algocetil" @default.
- NCIT_C850 hasExactSynonym "Apo-Sulin" @default.
- NCIT_C850 hasExactSynonym "Arthrocine" @default.
- NCIT_C850 hasExactSynonym "Artribid" @default.
- NCIT_C850 hasExactSynonym "Citireuma" @default.
- NCIT_C850 hasExactSynonym "Clinoril" @default.
- NCIT_C850 hasExactSynonym "Clisundac" @default.
- NCIT_C850 hasExactSynonym "Imbaral" @default.
- NCIT_C850 hasExactSynonym "MK-231" @default.
- NCIT_C850 hasExactSynonym "Novo-Sundac" @default.
- NCIT_C850 hasExactSynonym "Reumofil" @default.
- NCIT_C850 hasExactSynonym "Reumyl" @default.
- NCIT_C850 hasExactSynonym "SULINDAC" @default.
- NCIT_C850 hasExactSynonym "Sudac" @default.
- NCIT_C850 hasExactSynonym "Sulindac Sulfoxide" @default.
- NCIT_C850 hasExactSynonym "Sulindac" @default.
- NCIT_C850 hasExactSynonym "Sulinol" @default.
- NCIT_C850 hasExactSynonym "Sulreuma" @default.
- NCIT_C850 hasExactSynonym "cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid" @default.
- NCIT_C850 hasExactSynonym "sulindac" @default.
- NCIT_C850 inSubset NCIT_C116977 @default.
- NCIT_C850 inSubset NCIT_C116978 @default.
- NCIT_C850 inSubset NCIT_C128784 @default.
- NCIT_C850 inSubset NCIT_C157711 @default.
- NCIT_C850 inSubset NCIT_C157712 @default.
- NCIT_C850 inSubset NCIT_C176424 @default.
- NCIT_C850 inSubset NCIT_C177537 @default.
- NCIT_C850 inSubset NCIT_C63923 @default.
- NCIT_C850 type Class @default.
- NCIT_C850 isDefinedBy ncit.owl @default.
- NCIT_C850 label "Sulindac" @default.
- NCIT_C850 subClassOf NCIT_C1908 @default.
- NCIT_C850 subClassOf NCIT_C1909 @default.
- NCIT_C850 subClassOf NCIT_C2127 @default.
- NCIT_C850 subClassOf NCIT_C471 @default.
- NCIT_C850 subClassOf NCIT_C744 @default.
- NCIT_C850 subClassOf NCIT_C850 @default.