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- NCIT_C853 IAO_0000115 "A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04)" @default.
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- NCIT_C853 NCIT_A7 NCIT_C41029 @default.
- NCIT_C853 NCIT_NHC0 "C853" @default.
- NCIT_C853 NCIT_P106 "Organic Chemical" @default.
- NCIT_C853 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C853 NCIT_P107 "Suramin" @default.
- NCIT_C853 NCIT_P108 "Suramin" @default.
- NCIT_C853 NCIT_P207 "C0038880" @default.
- NCIT_C853 NCIT_P210 "145-63-1" @default.
- NCIT_C853 NCIT_P302 "Trypanosomiasis; hormone-refractory prostate cancer" @default.
- NCIT_C853 NCIT_P319 "6032D45BEM" @default.
- NCIT_C853 NCIT_P322 "CTRP" @default.
- NCIT_C853 NCIT_P322 "FDA" @default.
- NCIT_C853 NCIT_P322 "GDC" @default.
- NCIT_C853 NCIT_P325 "A drug that is used to treat infections caused by parasites. It is also being studied in the treatment of cancer. It belongs to the families of drugs called antiprotozoals and anthelmintics." @default.
- NCIT_C853 NCIT_P329 "40052" @default.
- NCIT_C853 NCIT_P330 "40052" @default.
- NCIT_C853 NCIT_P350 "C51H40N6O23S6" @default.
- NCIT_C853 NCIT_P366 "Suramin" @default.
- NCIT_C853 NCIT_P368 "CHEBI:45906" @default.
- NCIT_C853 NCIT_P375 "Suramin" @default.
- NCIT_C853 NCIT_P399 "40052" @default.
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- NCIT_C853 NCIT_R125 NCIT_C17932 @default.
- NCIT_C853 NCIT_R125 NCIT_C21124 @default.
- NCIT_C853 NCIT_R125 NCIT_C21128 @default.
- NCIT_C853 NCIT_R125 NCIT_C21147 @default.
- NCIT_C853 NCIT_R125 NCIT_C26044 @default.
- NCIT_C853 NCIT_R125 NCIT_C40767 @default.
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- NCIT_C853 NCIT_R72 NCIT_C12219 @default.
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- NCIT_C853 NCIT_R72 NCIT_C12481 @default.
- NCIT_C853 NCIT_R72 NCIT_C12508 @default.
- NCIT_C853 NCIT_R72 NCIT_C12555 @default.
- NCIT_C853 NCIT_R72 NCIT_C12801 @default.
- NCIT_C853 NCIT_R72 NCIT_C12865 @default.
- NCIT_C853 NCIT_R72 NCIT_C12964 @default.
- NCIT_C853 NCIT_R72 NCIT_C21599 @default.
- NCIT_C853 normalizedInformationContent "81.252167948509552" @default.
- NCIT_C853 referenceCount "17" @default.
- NCIT_C853 hasExactSynonym "SURAMIN" @default.
- NCIT_C853 hasExactSynonym "Suramin" @default.
- NCIT_C853 hasExactSynonym "suramin" @default.
- NCIT_C853 inSubset NCIT_C116977 @default.
- NCIT_C853 inSubset NCIT_C116978 @default.
- NCIT_C853 inSubset NCIT_C128784 @default.
- NCIT_C853 inSubset NCIT_C157711 @default.
- NCIT_C853 inSubset NCIT_C157712 @default.
- NCIT_C853 inSubset NCIT_C176424 @default.
- NCIT_C853 inSubset NCIT_C177537 @default.
- NCIT_C853 inSubset NCIT_C63923 @default.
- NCIT_C853 type Class @default.
- NCIT_C853 isDefinedBy ncit.owl @default.
- NCIT_C853 label "Suramin" @default.
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- NCIT_C853 subClassOf NCIT_C1971 @default.
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- NCIT_C853 subClassOf NCIT_C853 @default.