Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C85469> ?p ?o ?g. }
Showing items 1 to 47 of
47
with 100 items per page.
- NCIT_C85469 IAO_0000115 "A water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival." @default.
- NCIT_C85469 NCIT_A32 NCIT_C1909 @default.
- NCIT_C85469 NCIT_A7 NCIT_C17270 @default.
- NCIT_C85469 NCIT_NHC0 "C85469" @default.
- NCIT_C85469 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C85469 NCIT_P107 "pan-PI3K/mTOR Inhibitor SF1126" @default.
- NCIT_C85469 NCIT_P108 "pan-PI3K/mTOR Inhibitor SF1126" @default.
- NCIT_C85469 NCIT_P207 "C2351370" @default.
- NCIT_C85469 NCIT_P210 "936487-67-1" @default.
- NCIT_C85469 NCIT_P319 "DL0Q912033" @default.
- NCIT_C85469 NCIT_P322 "CTRP" @default.
- NCIT_C85469 NCIT_P322 "FDA" @default.
- NCIT_C85469 NCIT_P322 "GDC" @default.
- NCIT_C85469 NCIT_P329 "644818" @default.
- NCIT_C85469 NCIT_P330 "644818" @default.
- NCIT_C85469 NCIT_P375 "pan-PI3K/mTOR Inhibitor SF1126" @default.
- NCIT_C85469 NCIT_P399 "644818" @default.
- NCIT_C85469 normalizedInformationContent "100" @default.
- NCIT_C85469 referenceCount "1" @default.
- NCIT_C85469 hasExactSynonym "SF-1126" @default.
- NCIT_C85469 hasExactSynonym "SF1126" @default.
- NCIT_C85469 hasExactSynonym "pan-PI3K/mTOR Inhibitor SF1126" @default.
- NCIT_C85469 inSubset NCIT_C116977 @default.
- NCIT_C85469 inSubset NCIT_C116978 @default.
- NCIT_C85469 inSubset NCIT_C128784 @default.
- NCIT_C85469 inSubset NCIT_C157711 @default.
- NCIT_C85469 inSubset NCIT_C157712 @default.
- NCIT_C85469 inSubset NCIT_C176424 @default.
- NCIT_C85469 inSubset NCIT_C177537 @default.
- NCIT_C85469 inSubset NCIT_C63923 @default.
- NCIT_C85469 type Class @default.
- NCIT_C85469 isDefinedBy ncit.owl @default.
- NCIT_C85469 label "pan-PI3K/mTOR Inhibitor SF1126" @default.
- NCIT_C85469 subClassOf NCIT_C129824 @default.
- NCIT_C85469 subClassOf NCIT_C129825 @default.
- NCIT_C85469 subClassOf NCIT_C1404 @default.
- NCIT_C85469 subClassOf NCIT_C163758 @default.
- NCIT_C85469 subClassOf NCIT_C1742 @default.
- NCIT_C85469 subClassOf NCIT_C1908 @default.
- NCIT_C85469 subClassOf NCIT_C1909 @default.
- NCIT_C85469 subClassOf NCIT_C2152 @default.
- NCIT_C85469 subClassOf NCIT_C2189 @default.
- NCIT_C85469 subClassOf NCIT_C2201 @default.
- NCIT_C85469 subClassOf NCIT_C274 @default.
- NCIT_C85469 subClassOf NCIT_C471 @default.
- NCIT_C85469 subClassOf NCIT_C61074 @default.
- NCIT_C85469 subClassOf NCIT_C85469 @default.