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- NCIT_C85475 IAO_0000115 "A chimeric immunoglobulin G1 (IgG1) monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, zolbetuximab specifically targets and binds to CLDN18.2 expressed on tumor cells. This may kill CLDN18.2-expressing tumor cells by antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), and inhibit cell proliferation. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C85475 NCIT_A32 NCIT_C1909 @default.
- NCIT_C85475 NCIT_A7 NCIT_C150412 @default.
- NCIT_C85475 NCIT_NHC0 "C85475" @default.
- NCIT_C85475 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C85475 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C85475 NCIT_P107 "Zolbetuximab" @default.
- NCIT_C85475 NCIT_P108 "Zolbetuximab" @default.
- NCIT_C85475 NCIT_P208 "CL554291" @default.
- NCIT_C85475 NCIT_P210 "1496553-00-4" @default.
- NCIT_C85475 NCIT_P319 "TF5MPQ8WGY" @default.
- NCIT_C85475 NCIT_P322 "CTRP" @default.
- NCIT_C85475 NCIT_P322 "FDA" @default.
- NCIT_C85475 NCIT_P322 "GDC" @default.
- NCIT_C85475 NCIT_P329 "647103" @default.
- NCIT_C85475 NCIT_P330 "647103" @default.
- NCIT_C85475 NCIT_P375 "Zolbetuximab" @default.
- NCIT_C85475 NCIT_P399 "647103" @default.
- NCIT_C85475 NCIT_R124 NCIT_C17710 @default.
- NCIT_C85475 NCIT_R124 NCIT_C17828 @default.
- NCIT_C85475 NCIT_R124 NCIT_C18219 @default.
- NCIT_C85475 NCIT_R124 NCIT_C19986 @default.
- NCIT_C85475 NCIT_R124 NCIT_C40474 @default.
- NCIT_C85475 normalizedInformationContent "100" @default.
- NCIT_C85475 referenceCount "1" @default.
- NCIT_C85475 hasExactSynonym "Claudiximab" @default.
- NCIT_C85475 hasExactSynonym "IMAB 362" @default.
- NCIT_C85475 hasExactSynonym "IMAB-362" @default.
- NCIT_C85475 hasExactSynonym "IMAB362" @default.
- NCIT_C85475 hasExactSynonym "ZOLBETUXIMAB" @default.
- NCIT_C85475 hasExactSynonym "Zolbetuximab" @default.
- NCIT_C85475 inSubset NCIT_C116977 @default.
- NCIT_C85475 inSubset NCIT_C116978 @default.
- NCIT_C85475 inSubset NCIT_C128784 @default.
- NCIT_C85475 inSubset NCIT_C157711 @default.
- NCIT_C85475 inSubset NCIT_C157712 @default.
- NCIT_C85475 inSubset NCIT_C176424 @default.
- NCIT_C85475 inSubset NCIT_C177537 @default.
- NCIT_C85475 inSubset NCIT_C63923 @default.
- NCIT_C85475 type Class @default.
- NCIT_C85475 isDefinedBy ncit.owl @default.
- NCIT_C85475 label "Zolbetuximab" @default.
- NCIT_C85475 subClassOf NCIT_C129821 @default.
- NCIT_C85475 subClassOf NCIT_C129822 @default.
- NCIT_C85475 subClassOf NCIT_C163758 @default.
- NCIT_C85475 subClassOf NCIT_C179676 @default.
- NCIT_C85475 subClassOf NCIT_C1908 @default.
- NCIT_C85475 subClassOf NCIT_C1909 @default.
- NCIT_C85475 subClassOf NCIT_C200250 @default.
- NCIT_C85475 subClassOf NCIT_C20401 @default.
- NCIT_C85475 subClassOf NCIT_C274 @default.
- NCIT_C85475 subClassOf NCIT_C307 @default.
- NCIT_C85475 subClassOf NCIT_C308 @default.
- NCIT_C85475 subClassOf NCIT_C85475 @default.