Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C855> ?p ?o ?g. }
- NCIT_C855 IAO_0000115 "The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC." @default.
- NCIT_C855 NCIT_A32 NCIT_C1909 @default.
- NCIT_C855 NCIT_A6 NCIT_C62078 @default.
- NCIT_C855 NCIT_A7 NCIT_C38361 @default.
- NCIT_C855 NCIT_NHC0 "C855" @default.
- NCIT_C855 NCIT_P106 "Organic Chemical" @default.
- NCIT_C855 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C855 NCIT_P107 "Tamoxifen Citrate" @default.
- NCIT_C855 NCIT_P108 "Tamoxifen Citrate" @default.
- NCIT_C855 NCIT_P175 "180973" @default.
- NCIT_C855 NCIT_P207 "C0700621" @default.
- NCIT_C855 NCIT_P210 "54965-24-1" @default.
- NCIT_C855 NCIT_P302 "Breast cancer; Endometrial cancer; Gynecomastia; Melanoma; Ovarian cancer" @default.
- NCIT_C855 NCIT_P319 "7FRV7310N6" @default.
- NCIT_C855 NCIT_P322 "CTRP" @default.
- NCIT_C855 NCIT_P322 "FDA" @default.
- NCIT_C855 NCIT_P322 "GDC" @default.
- NCIT_C855 NCIT_P325 "A drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen citrate is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen citrate is a type of antiestrogen." @default.
- NCIT_C855 NCIT_P329 "42901" @default.
- NCIT_C855 NCIT_P330 "42901" @default.
- NCIT_C855 NCIT_P350 "C26H29NO.C6H8O7" @default.
- NCIT_C855 NCIT_P366 "Tamoxifen" @default.
- NCIT_C855 NCIT_P368 "CHEBI:9397" @default.
- NCIT_C855 NCIT_P375 "Tamoxifen Citrate" @default.
- NCIT_C855 NCIT_P399 "42901" @default.
- NCIT_C855 NCIT_R122 NCIT_C16484 @default.
- NCIT_C855 NCIT_R122 NCIT_C16486 @default.
- NCIT_C855 NCIT_R122 NCIT_C16554 @default.
- NCIT_C855 NCIT_R122 NCIT_C16865 @default.
- NCIT_C855 NCIT_R122 NCIT_C16946 @default.
- NCIT_C855 NCIT_R122 NCIT_C17021 @default.
- NCIT_C855 NCIT_R122 NCIT_C17287 @default.
- NCIT_C855 NCIT_R122 NCIT_C17573 @default.
- NCIT_C855 NCIT_R122 NCIT_C20027 @default.
- NCIT_C855 NCIT_R122 NCIT_C26548 @default.
- NCIT_C855 NCIT_R122 NCIT_C28459 @default.
- NCIT_C855 NCIT_R122 NCIT_C28750 @default.
- NCIT_C855 NCIT_R122 NCIT_C45999 @default.
- NCIT_C855 NCIT_R122 NCIT_C46000 @default.
- NCIT_C855 normalizedInformationContent "69.526842234962075" @default.
- NCIT_C855 referenceCount "100" @default.
- NCIT_C855 hasExactSynonym "(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate" @default.
- NCIT_C855 hasExactSynonym "(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate" @default.
- NCIT_C855 hasExactSynonym "1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene Citrate" @default.
- NCIT_C855 hasExactSynonym "Apo-Tamox" @default.
- NCIT_C855 hasExactSynonym "Clonoxifen" @default.
- NCIT_C855 hasExactSynonym "Dignotamoxi" @default.
- NCIT_C855 hasExactSynonym "Ebefen" @default.
- NCIT_C855 hasExactSynonym "Emblon" @default.
- NCIT_C855 hasExactSynonym "Estroxyn" @default.
- NCIT_C855 hasExactSynonym "Fentamox" @default.
- NCIT_C855 hasExactSynonym "Gen-Tamoxifen" @default.
- NCIT_C855 hasExactSynonym "Genox" @default.
- NCIT_C855 hasExactSynonym "ICI 46,474" @default.
- NCIT_C855 hasExactSynonym "ICI-46474" @default.
- NCIT_C855 hasExactSynonym "Jenoxifen" @default.
- NCIT_C855 hasExactSynonym "Kessar" @default.
- NCIT_C855 hasExactSynonym "Ledertam" @default.
- NCIT_C855 hasExactSynonym "Lesporene" @default.
- NCIT_C855 hasExactSynonym "Nolgen" @default.
- NCIT_C855 hasExactSynonym "Noltam" @default.
- NCIT_C855 hasExactSynonym "Nolvadex" @default.
- NCIT_C855 hasExactSynonym "Nolvadex-D" @default.
- NCIT_C855 hasExactSynonym "Nourytam" @default.
- NCIT_C855 hasExactSynonym "Novo-Tamoxifen" @default.
- NCIT_C855 hasExactSynonym "Novofen" @default.
- NCIT_C855 hasExactSynonym "Noxitem" @default.
- NCIT_C855 hasExactSynonym "Oestrifen" @default.
- NCIT_C855 hasExactSynonym "Oncotam" @default.
- NCIT_C855 hasExactSynonym "PMS-Tamoxifen" @default.
- NCIT_C855 hasExactSynonym "Soltamox" @default.
- NCIT_C855 hasExactSynonym "TAM" @default.
- NCIT_C855 hasExactSynonym "TAMOXIFEN CITRATE" @default.
- NCIT_C855 hasExactSynonym "Tamax" @default.
- NCIT_C855 hasExactSynonym "Tamaxin" @default.
- NCIT_C855 hasExactSynonym "Tamifen" @default.
- NCIT_C855 hasExactSynonym "Tamizam" @default.
- NCIT_C855 hasExactSynonym "Tamofen" @default.
- NCIT_C855 hasExactSynonym "Tamoxasta" @default.
- NCIT_C855 hasExactSynonym "Tamoxifen Citrate" @default.
- NCIT_C855 hasExactSynonym "Tamoxifen citrate" @default.
- NCIT_C855 hasExactSynonym "Tamoxifeni Citras" @default.
- NCIT_C855 hasExactSynonym "Zemide" @default.
- NCIT_C855 hasExactSynonym "tamoxifen citrate" @default.
- NCIT_C855 inSubset NCIT_C116977 @default.
- NCIT_C855 inSubset NCIT_C116978 @default.
- NCIT_C855 inSubset NCIT_C128784 @default.
- NCIT_C855 inSubset NCIT_C157711 @default.
- NCIT_C855 inSubset NCIT_C157712 @default.
- NCIT_C855 inSubset NCIT_C176424 @default.
- NCIT_C855 inSubset NCIT_C177537 @default.
- NCIT_C855 inSubset NCIT_C63923 @default.
- NCIT_C855 type Class @default.
- NCIT_C855 isDefinedBy ncit.owl @default.
- NCIT_C855 label "Tamoxifen Citrate" @default.
- NCIT_C855 subClassOf B39a81ed36a23eb92f6d881f3553c9923 @default.
- NCIT_C855 subClassOf B3f36c5b8c45138c7e8a5dc52cff428d9 @default.
- NCIT_C855 subClassOf B43a118ac04cca04c07224961e64e3557 @default.
- NCIT_C855 subClassOf B71c9a03b67e5e9756fb9199c9ca677bf @default.
- NCIT_C855 subClassOf Bb1a50e36d0cdc548816cd5390a27a475 @default.