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- NCIT_C85523 IAO_0000115 "A thiosemicarbazone prodrug with antitubercular activity. Although the exact mechanism by which thioacetazone exerts its effect has yet to be fully elucidated, this agent, upon activation by bacterial monooxygenase EtaA, appears to target and inhibit cyclopropane mycolic acid synthases (CMASs), a family of S-adenosyl-methionine-dependent methyl transferases responsible for cyclopropanation of mycolic acid. By inhibiting mycolic acid synthesis, the bacterial cell wall becomes more permeable and less resistant to injury which eventually leads to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence." @default.
- NCIT_C85523 NCIT_NHC0 "C85523" @default.
- NCIT_C85523 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C85523 NCIT_P108 "Thioacetazone" @default.
- NCIT_C85523 NCIT_P207 "C0039834" @default.
- NCIT_C85523 NCIT_P210 "104-06-3" @default.
- NCIT_C85523 normalizedInformationContent "100" @default.
- NCIT_C85523 referenceCount "1" @default.
- NCIT_C85523 hasExactSynonym "N-(4-(ethanethioamidoimino)methylphenyl)acetamide" @default.
- NCIT_C85523 hasExactSynonym "Thiacetazone" @default.
- NCIT_C85523 hasExactSynonym "Thioacetazone" @default.
- NCIT_C85523 type Class @default.
- NCIT_C85523 isDefinedBy ncit.owl @default.
- NCIT_C85523 label "Thioacetazone" @default.
- NCIT_C85523 subClassOf NCIT_C1908 @default.
- NCIT_C85523 subClassOf NCIT_C1909 @default.
- NCIT_C85523 subClassOf NCIT_C254 @default.
- NCIT_C85523 subClassOf NCIT_C280 @default.
- NCIT_C85523 subClassOf NCIT_C52588 @default.
- NCIT_C85523 subClassOf NCIT_C85523 @default.