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- NCIT_C862 IAO_0000115 "A synthetic form of the endogenous androgenic steroid testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes. DHT binds with higher affinity to androgen receptors than testosterone, activating gene expression more efficiently. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative." @default.
- NCIT_C862 NCIT_A7 NCIT_C17063 @default.
- NCIT_C862 NCIT_A9 NCIT_C2299 @default.
- NCIT_C862 NCIT_NHC0 "C862" @default.
- NCIT_C862 NCIT_P106 "Organic Chemical" @default.
- NCIT_C862 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C862 NCIT_P107 "Therapeutic Testosterone" @default.
- NCIT_C862 NCIT_P108 "Therapeutic Testosterone" @default.
- NCIT_C862 NCIT_P175 "9700" @default.
- NCIT_C862 NCIT_P208 "CL1379971" @default.
- NCIT_C862 NCIT_P210 "58-22-0" @default.
- NCIT_C862 NCIT_P302 "Delayed puberty, male; Hypogonadism; Metastatic mammary cancer" @default.
- NCIT_C862 NCIT_P319 "3XMK78S47O" @default.
- NCIT_C862 NCIT_P322 "CTRP" @default.
- NCIT_C862 NCIT_P322 "FDA" @default.
- NCIT_C862 NCIT_P329 "42926" @default.
- NCIT_C862 NCIT_P330 "42926" @default.
- NCIT_C862 NCIT_P350 "C19H28O2" @default.
- NCIT_C862 NCIT_P366 "Therapeutic_Testosterone" @default.
- NCIT_C862 NCIT_P368 "CHEBI:17347" @default.
- NCIT_C862 NCIT_P399 "42926" @default.
- NCIT_C862 NCIT_R122 NCIT_C16484 @default.
- NCIT_C862 NCIT_R122 NCIT_C16486 @default.
- NCIT_C862 NCIT_R122 NCIT_C16554 @default.
- NCIT_C862 NCIT_R122 NCIT_C16865 @default.
- NCIT_C862 NCIT_R122 NCIT_C16946 @default.
- NCIT_C862 NCIT_R122 NCIT_C17021 @default.
- NCIT_C862 NCIT_R122 NCIT_C17573 @default.
- NCIT_C862 NCIT_R122 NCIT_C20027 @default.
- NCIT_C862 NCIT_R122 NCIT_C26548 @default.
- NCIT_C862 NCIT_R122 NCIT_C28459 @default.
- NCIT_C862 NCIT_R122 NCIT_C45999 @default.
- NCIT_C862 NCIT_R122 NCIT_C46000 @default.
- NCIT_C862 normalizedInformationContent "83.556969816060246" @default.
- NCIT_C862 referenceCount "12" @default.
- NCIT_C862 hasExactSynonym "(17Beta)-17-hydroxyandrost-4-en-3-one" @default.
- NCIT_C862 hasExactSynonym "Delta4-Androsten-17beta-ol-3-one" @default.
- NCIT_C862 hasExactSynonym "Mertestate" @default.
- NCIT_C862 hasExactSynonym "TESTOSTERONE" @default.
- NCIT_C862 hasExactSynonym "Testoderm" @default.
- NCIT_C862 hasExactSynonym "Testolin" @default.
- NCIT_C862 hasExactSynonym "Testosterone" @default.
- NCIT_C862 hasExactSynonym "Testostroval" @default.
- NCIT_C862 hasExactSynonym "Testostroval-PA" @default.
- NCIT_C862 hasExactSynonym "Testro AQ" @default.
- NCIT_C862 hasExactSynonym "Therapeutic Testosterone" @default.
- NCIT_C862 hasExactSynonym "Trans-Testosterone" @default.
- NCIT_C862 hasExactSynonym "Virosterone" @default.
- NCIT_C862 inSubset NCIT_C116977 @default.
- NCIT_C862 inSubset NCIT_C116978 @default.
- NCIT_C862 inSubset NCIT_C176424 @default.
- NCIT_C862 inSubset NCIT_C63923 @default.
- NCIT_C862 type Class @default.
- NCIT_C862 isDefinedBy ncit.owl @default.
- NCIT_C862 label "Therapeutic Testosterone" @default.
- NCIT_C862 subClassOf B0a037b6bcfb3cde10876de29ea341ac4 @default.
- NCIT_C862 subClassOf B425d537256082ae526b735efb5c65084 @default.
- NCIT_C862 subClassOf B4622a5bfa3d2050a9a3897a161ca36f6 @default.
- NCIT_C862 subClassOf B4eaa74e7af73fc07cc2d0ca342d19fdb @default.
- NCIT_C862 subClassOf B8a8ad745c3042f01c81a7b902ed1bf68 @default.
- NCIT_C862 subClassOf Bf9f9ebbeaa188b0c518c2e3a2595748a @default.
- NCIT_C862 subClassOf NCIT_C147908 @default.
- NCIT_C862 subClassOf NCIT_C1636 @default.
- NCIT_C862 subClassOf NCIT_C1908 @default.
- NCIT_C862 subClassOf NCIT_C1909 @default.
- NCIT_C862 subClassOf NCIT_C1913 @default.
- NCIT_C862 subClassOf NCIT_C2360 @default.
- NCIT_C862 subClassOf NCIT_C243 @default.
- NCIT_C862 subClassOf NCIT_C548 @default.
- NCIT_C862 subClassOf NCIT_C616 @default.
- NCIT_C862 subClassOf NCIT_C718 @default.
- NCIT_C862 subClassOf NCIT_C843 @default.
- NCIT_C862 subClassOf NCIT_C862 @default.