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- NCIT_C868 IAO_0000115 "A synthetic pyrimidine nucleoside analogue with biomodulating activity. Tetrahydrouridine increases the efficacy of the radiosensitizer cytochlor (5-chloro-2'-deoxycytidine) by inhibiting the enzyme deoxycytidine monophosphate (dCMP) deaminase and preventing the premature deamination of the cytochlor metabolite 5-chloro-2'-deoxycytidine monophosphate (CldCMP) to 5-chloro-2'-deoxyuridine monophosphate (CldUMP); in turn, this increases tumor concentrations of CldUMP which is then further anabolized and incorporated selectively into tumor DNA as CldU (5-chloro-2'-deoxyuridine). (NCI04)" @default.
- NCIT_C868 NCIT_A32 NCIT_C1909 @default.
- NCIT_C868 NCIT_A7 NCIT_C53621 @default.
- NCIT_C868 NCIT_NHC0 "C868" @default.
- NCIT_C868 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C868 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C868 NCIT_P107 "Tetrahydrouridine" @default.
- NCIT_C868 NCIT_P108 "Tetrahydrouridine" @default.
- NCIT_C868 NCIT_P175 "112907" @default.
- NCIT_C868 NCIT_P207 "C0039677" @default.
- NCIT_C868 NCIT_P210 "18771-50-1" @default.
- NCIT_C868 NCIT_P319 "0NIZ8H6OL8" @default.
- NCIT_C868 NCIT_P322 "CTRP" @default.
- NCIT_C868 NCIT_P322 "FDA" @default.
- NCIT_C868 NCIT_P322 "GDC" @default.
- NCIT_C868 NCIT_P325 "A substance that makes tumor cells more sensitive to radiation therapy and is being studied in the treatment of cancer. It belongs to the families of drugs called cytidine deaminase inhibitors, multidrug resistance modulators, and radiosensitizers." @default.
- NCIT_C868 NCIT_P329 "39710" @default.
- NCIT_C868 NCIT_P330 "39710" @default.
- NCIT_C868 NCIT_P366 "Tetrahydrouridine" @default.
- NCIT_C868 NCIT_P375 "Tetrahydrouridine" @default.
- NCIT_C868 NCIT_P399 "39710" @default.
- NCIT_C868 NCIT_R124 NCIT_C17710 @default.
- NCIT_C868 NCIT_R124 NCIT_C17828 @default.
- NCIT_C868 NCIT_R124 NCIT_C28498 @default.
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- NCIT_C868 NCIT_R124 NCIT_C40577 @default.
- NCIT_C868 NCIT_R125 NCIT_C17710 @default.
- NCIT_C868 NCIT_R125 NCIT_C17828 @default.
- NCIT_C868 NCIT_R125 NCIT_C18125 @default.
- NCIT_C868 NCIT_R125 NCIT_C20150 @default.
- NCIT_C868 NCIT_R125 NCIT_C20480 @default.
- NCIT_C868 NCIT_R125 NCIT_C21080 @default.
- NCIT_C868 NCIT_R125 NCIT_C28498 @default.
- NCIT_C868 NCIT_R125 NCIT_C40664 @default.
- NCIT_C868 NCIT_R125 NCIT_C40715 @default.
- NCIT_C868 NCIT_R125 NCIT_C41515 @default.
- NCIT_C868 NCIT_R125 NCIT_C41543 @default.
- NCIT_C868 NCIT_R125 NCIT_C51037 @default.
- NCIT_C868 NCIT_R146 NCIT_C16554 @default.
- NCIT_C868 NCIT_R146 NCIT_C16701 @default.
- NCIT_C868 NCIT_R146 NCIT_C17021 @default.
- NCIT_C868 NCIT_R146 NCIT_C20027 @default.
- NCIT_C868 NCIT_R146 NCIT_C26548 @default.
- NCIT_C868 NCIT_R146 NCIT_C48963 @default.
- NCIT_C868 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C868 referenceCount "2" @default.
- NCIT_C868 hasExactSynonym "2(1H)-pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-" @default.
- NCIT_C868 hasExactSynonym "TETRAHYDROURIDINE" @default.
- NCIT_C868 hasExactSynonym "THU" @default.
- NCIT_C868 hasExactSynonym "Tetrahydrouridine" @default.
- NCIT_C868 hasExactSynonym "tetrahydrouridine" @default.
- NCIT_C868 inSubset NCIT_C116977 @default.
- NCIT_C868 inSubset NCIT_C116978 @default.
- NCIT_C868 inSubset NCIT_C128784 @default.
- NCIT_C868 inSubset NCIT_C157711 @default.
- NCIT_C868 inSubset NCIT_C157712 @default.
- NCIT_C868 inSubset NCIT_C176424 @default.
- NCIT_C868 inSubset NCIT_C177537 @default.
- NCIT_C868 inSubset NCIT_C63923 @default.
- NCIT_C868 type Class @default.
- NCIT_C868 isDefinedBy ncit.owl @default.
- NCIT_C868 label "Tetrahydrouridine" @default.
- NCIT_C868 subClassOf B2d329551f2837f87772b0c33d8e17e98 @default.
- NCIT_C868 subClassOf B3ea8379330253abfa54e371c90fb732d @default.
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- NCIT_C868 subClassOf NCIT_C1557 @default.
- NCIT_C868 subClassOf NCIT_C186664 @default.
- NCIT_C868 subClassOf NCIT_C1908 @default.
- NCIT_C868 subClassOf NCIT_C1909 @default.
- NCIT_C868 subClassOf NCIT_C2135 @default.
- NCIT_C868 subClassOf NCIT_C272 @default.
- NCIT_C868 subClassOf NCIT_C274 @default.
- NCIT_C868 subClassOf NCIT_C471 @default.
- NCIT_C868 subClassOf NCIT_C868 @default.