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- NCIT_C87056 IAO_0000115 "A combination preparation containing the belladonna alkaloids atropine sulfate, hyoscyamine sulfate, and scopolamine hydrobromide, and the barbiturate phenobarbital with antispasmodic, anxiolytic and sedative activities. The belladonna alkaloids bind to and block muscarinic receptors in the gastrointestinal (GI) tract. This leads to a decrease in stomach secretions, GI motility and GI spasms. Phenobarbital binds to a distinct site on the gamma-aminobutyric acid (GABA)-A subtype receptor in the central nervous system (CNS), thereby increasing the influx of chloride ions into the neuron and potentiating GABA-induced increases in chloride conductance. This enhances postsynaptic responses to the inhibitory actions of GABA and causes CNS depression." @default.
- NCIT_C87056 NCIT_NHC0 "C87056" @default.
- NCIT_C87056 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C87056 NCIT_P108 "Belladonna/Phenobarbital" @default.
- NCIT_C87056 NCIT_P207 "C0718861" @default.
- NCIT_C87056 normalizedInformationContent "100" @default.
- NCIT_C87056 referenceCount "1" @default.
- NCIT_C87056 hasExactSynonym "Belladonna Alkaloids/Phenobarbital" @default.
- NCIT_C87056 hasExactSynonym "Belladonna/Phenobarbital" @default.
- NCIT_C87056 type Class @default.
- NCIT_C87056 isDefinedBy ncit.owl @default.
- NCIT_C87056 label "Belladonna/Phenobarbital" @default.
- NCIT_C87056 subClassOf NCIT_C1908 @default.
- NCIT_C87056 subClassOf NCIT_C1909 @default.
- NCIT_C87056 subClassOf NCIT_C29629 @default.
- NCIT_C87056 subClassOf NCIT_C87056 @default.