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- NCIT_C87346 IAO_0000115 "An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation." @default.
- NCIT_C87346 NCIT_A32 NCIT_C1909 @default.
- NCIT_C87346 NCIT_NHC0 "C87346" @default.
- NCIT_C87346 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C87346 NCIT_P107 "Sodium Selenite" @default.
- NCIT_C87346 NCIT_P108 "Sodium Selenite" @default.
- NCIT_C87346 NCIT_P207 "C0142923" @default.
- NCIT_C87346 NCIT_P210 "10102-18-8" @default.
- NCIT_C87346 NCIT_P319 "HIW548RQ3W" @default.
- NCIT_C87346 NCIT_P322 "CTRP" @default.
- NCIT_C87346 NCIT_P322 "FDA" @default.
- NCIT_C87346 NCIT_P322 "GDC" @default.
- NCIT_C87346 NCIT_P329 "681583" @default.
- NCIT_C87346 NCIT_P330 "681583" @default.
- NCIT_C87346 NCIT_P350 "2Na.O3Se" @default.
- NCIT_C87346 NCIT_P368 "CHEBI:48843" @default.
- NCIT_C87346 NCIT_P375 "Sodium Selenite" @default.
- NCIT_C87346 NCIT_P399 "681583" @default.
- NCIT_C87346 normalizedInformationContent "100" @default.
- NCIT_C87346 referenceCount "1" @default.
- NCIT_C87346 hasExactSynonym "Disodium Selenium Trioxide" @default.
- NCIT_C87346 hasExactSynonym "SODIUM SELENITE" @default.
- NCIT_C87346 hasExactSynonym "Selenious Acid Disodium Salt" @default.
- NCIT_C87346 hasExactSynonym "Selenious Acid, Sodium Salt (1:2)" @default.
- NCIT_C87346 hasExactSynonym "Sodium Selenite" @default.
- NCIT_C87346 inSubset NCIT_C116977 @default.
- NCIT_C87346 inSubset NCIT_C116978 @default.
- NCIT_C87346 inSubset NCIT_C128784 @default.
- NCIT_C87346 inSubset NCIT_C157711 @default.
- NCIT_C87346 inSubset NCIT_C157712 @default.
- NCIT_C87346 inSubset NCIT_C176424 @default.
- NCIT_C87346 inSubset NCIT_C177537 @default.
- NCIT_C87346 inSubset NCIT_C63923 @default.
- NCIT_C87346 type Class @default.
- NCIT_C87346 isDefinedBy ncit.owl @default.
- NCIT_C87346 label "Sodium Selenite" @default.
- NCIT_C87346 subClassOf NCIT_C1505 @default.
- NCIT_C87346 subClassOf NCIT_C1908 @default.
- NCIT_C87346 subClassOf NCIT_C87346 @default.