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- NCIT_C875 IAO_0000115 "A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth." @default.
- NCIT_C875 NCIT_A24 NCIT_C274 @default.
- NCIT_C875 NCIT_A32 NCIT_C1909 @default.
- NCIT_C875 NCIT_NHC0 "C875" @default.
- NCIT_C875 NCIT_P106 "Organic Chemical" @default.
- NCIT_C875 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C875 NCIT_P107 "Thiotepa" @default.
- NCIT_C875 NCIT_P108 "Thiotepa" @default.
- NCIT_C875 NCIT_P175 "6396" @default.
- NCIT_C875 NCIT_P207 "C0039871" @default.
- NCIT_C875 NCIT_P210 "52-24-4" @default.
- NCIT_C875 NCIT_P302 "Bladder cancer; Breast cancer; Ovarian cancer; Hodgkins lymphoma; Non-hodgkins lymphoma" @default.
- NCIT_C875 NCIT_P319 "905Z5W3GKH" @default.
- NCIT_C875 NCIT_P322 "CTRP" @default.
- NCIT_C875 NCIT_P322 "FDA" @default.
- NCIT_C875 NCIT_P322 "GDC" @default.
- NCIT_C875 NCIT_P322 "PCDC" @default.
- NCIT_C875 NCIT_P325 "An anticancer drug that belongs to the family of drugs called alkylating agents." @default.
- NCIT_C875 NCIT_P329 "42933" @default.
- NCIT_C875 NCIT_P330 "42933" @default.
- NCIT_C875 NCIT_P350 "C6H12N3PS" @default.
- NCIT_C875 NCIT_P366 "Thiotepa" @default.
- NCIT_C875 NCIT_P375 "Thiotepa" @default.
- NCIT_C875 NCIT_P399 "42933" @default.
- NCIT_C875 normalizedInformationContent "72.078833398632369" @default.
- NCIT_C875 referenceCount "68" @default.
- NCIT_C875 hasExactSynonym "1,1',1"-phosphinothioylidynetrisaziridine" @default.
- NCIT_C875 hasExactSynonym "1,1',1''-Phosphinothioyldynetrisaziridine" @default.
- NCIT_C875 hasExactSynonym "1,1',1''-Phosphinothioylidynetrisaziridine" @default.
- NCIT_C875 hasExactSynonym "Girostan" @default.
- NCIT_C875 hasExactSynonym "N,N', N''-Triethylenethiophosphoramide" @default.
- NCIT_C875 hasExactSynonym "N,N',N''-triethylenethiophosphoramide" @default.
- NCIT_C875 hasExactSynonym "Oncotiotepa" @default.
- NCIT_C875 hasExactSynonym "STEPA" @default.
- NCIT_C875 hasExactSynonym "TESPA" @default.
- NCIT_C875 hasExactSynonym "THIOTEPA" @default.
- NCIT_C875 hasExactSynonym "TIO TEF" @default.
- NCIT_C875 hasExactSynonym "TSPA" @default.
- NCIT_C875 hasExactSynonym "Tepadina" @default.
- NCIT_C875 hasExactSynonym "Tespamin" @default.
- NCIT_C875 hasExactSynonym "Tespamine" @default.
- NCIT_C875 hasExactSynonym "Thio-Tepa" @default.
- NCIT_C875 hasExactSynonym "Thiofosfamide" @default.
- NCIT_C875 hasExactSynonym "Thiofozil" @default.
- NCIT_C875 hasExactSynonym "Thiophosphamide" @default.
- NCIT_C875 hasExactSynonym "Thiophosphoamide" @default.
- NCIT_C875 hasExactSynonym "Thiophosphoramide" @default.
- NCIT_C875 hasExactSynonym "Thioplex" @default.
- NCIT_C875 hasExactSynonym "Thiotef" @default.
- NCIT_C875 hasExactSynonym "Thiotepa" @default.
- NCIT_C875 hasExactSynonym "Tifosyl" @default.
- NCIT_C875 hasExactSynonym "Tio-tef" @default.
- NCIT_C875 hasExactSynonym "Triethylene Thiophosphoramide" @default.
- NCIT_C875 hasExactSynonym "Triethylene thiophosphoramide" @default.
- NCIT_C875 hasExactSynonym "Triethylenethiophosphoramide" @default.
- NCIT_C875 hasExactSynonym "Tris(1-aziridinyl)phosphine sulfide" @default.
- NCIT_C875 hasExactSynonym "WR 45312" @default.
- NCIT_C875 hasExactSynonym "thiotepa" @default.
- NCIT_C875 hasExactSynonym "triethylenethiophosphoramide" @default.
- NCIT_C875 hasExactSynonym "tris(1-aziridinyl)phosphine sulfide" @default.
- NCIT_C875 inSubset NCIT_C116977 @default.
- NCIT_C875 inSubset NCIT_C116978 @default.
- NCIT_C875 inSubset NCIT_C128784 @default.
- NCIT_C875 inSubset NCIT_C157711 @default.
- NCIT_C875 inSubset NCIT_C157712 @default.
- NCIT_C875 inSubset NCIT_C173234 @default.
- NCIT_C875 inSubset NCIT_C174019 @default.
- NCIT_C875 inSubset NCIT_C176424 @default.
- NCIT_C875 inSubset NCIT_C177537 @default.
- NCIT_C875 inSubset NCIT_C186327 @default.
- NCIT_C875 inSubset NCIT_C186328 @default.
- NCIT_C875 inSubset NCIT_C186341 @default.
- NCIT_C875 inSubset NCIT_C63923 @default.
- NCIT_C875 type Class @default.
- NCIT_C875 isDefinedBy ncit.owl @default.
- NCIT_C875 label "Thiotepa" @default.
- NCIT_C875 subClassOf NCIT_C1590 @default.
- NCIT_C875 subClassOf NCIT_C186664 @default.
- NCIT_C875 subClassOf NCIT_C1908 @default.
- NCIT_C875 subClassOf NCIT_C1909 @default.
- NCIT_C875 subClassOf NCIT_C274 @default.
- NCIT_C875 subClassOf NCIT_C2842 @default.
- NCIT_C875 subClassOf NCIT_C292 @default.
- NCIT_C875 subClassOf NCIT_C875 @default.