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- NCIT_C87658 IAO_0000115 "An orally bioavailable diarylquinoline antimycobacterial agent, that can be used in the treatment of pulmonary multi-drug resistant tuberculosis (MDR-TB). Upon oral administration, bedaquiline specifically binds to subunit c of Mycobacterium tuberculosis (M. tuberculosis) adenosine 5'-triphosphate (ATP) synthase, thereby preventing ATP synthase activity. This inhibits ATP synthesis in M. tuberculosis, thereby blocking its energy metabolism and killing M. tuberculosis." @default.
- NCIT_C87658 NCIT_NHC0 "C87658" @default.
- NCIT_C87658 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C87658 NCIT_P107 "Bedaquiline" @default.
- NCIT_C87658 NCIT_P108 "Bedaquiline" @default.
- NCIT_C87658 NCIT_P207 "C1664205" @default.
- NCIT_C87658 NCIT_P210 "843663-66-1" @default.
- NCIT_C87658 NCIT_P319 "78846I289Y" @default.
- NCIT_C87658 NCIT_P322 "CTRP" @default.
- NCIT_C87658 NCIT_P322 "FDA" @default.
- NCIT_C87658 NCIT_P350 "C32H31BrN2O2" @default.
- NCIT_C87658 NCIT_P399 "811246" @default.
- NCIT_C87658 normalizedInformationContent "100" @default.
- NCIT_C87658 referenceCount "1" @default.
- NCIT_C87658 hasExactSynonym "1-(6-bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-(3-fluorophenyl)-1-phenyl-butan-2-ol" @default.
- NCIT_C87658 hasExactSynonym "3-Quinolineethanol, 6-Bromo-Alpha-(2-(Dimethylamino)Ethyl)-2-Methoxy-Alpha-1-Naphthalenyl-Beta-Phenyl-, (Alpha-S,Beta-R)-" @default.
- NCIT_C87658 hasExactSynonym "BEDAQUILINE" @default.
- NCIT_C87658 hasExactSynonym "Bedaquiline" @default.
- NCIT_C87658 hasExactSynonym "R207910" @default.
- NCIT_C87658 hasExactSynonym "TMC207" @default.
- NCIT_C87658 inSubset NCIT_C116977 @default.
- NCIT_C87658 inSubset NCIT_C116978 @default.
- NCIT_C87658 inSubset NCIT_C176424 @default.
- NCIT_C87658 inSubset NCIT_C63923 @default.
- NCIT_C87658 type Class @default.
- NCIT_C87658 isDefinedBy ncit.owl @default.
- NCIT_C87658 label "Bedaquiline" @default.
- NCIT_C87658 subClassOf NCIT_C1908 @default.
- NCIT_C87658 subClassOf NCIT_C1909 @default.
- NCIT_C87658 subClassOf NCIT_C254 @default.
- NCIT_C87658 subClassOf NCIT_C280 @default.
- NCIT_C87658 subClassOf NCIT_C52588 @default.
- NCIT_C87658 subClassOf NCIT_C87658 @default.