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- NCIT_C87728 IAO_0000115 "An orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types." @default.
- NCIT_C87728 NCIT_A32 NCIT_C1909 @default.
- NCIT_C87728 NCIT_A7 NCIT_C105930 @default.
- NCIT_C87728 NCIT_NHC0 "C87728" @default.
- NCIT_C87728 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C87728 NCIT_P107 "Macitentan" @default.
- NCIT_C87728 NCIT_P108 "Macitentan" @default.
- NCIT_C87728 NCIT_P207 "C2606556" @default.
- NCIT_C87728 NCIT_P210 "441798-33-0" @default.
- NCIT_C87728 NCIT_P302 "Pulmonary arterial hypertension, idiopathic pulmonary fibrosis, oncology" @default.
- NCIT_C87728 NCIT_P319 "Z9K9Y9WMVL" @default.
- NCIT_C87728 NCIT_P322 "CTRP" @default.
- NCIT_C87728 NCIT_P322 "FDA" @default.
- NCIT_C87728 NCIT_P322 "GDC" @default.
- NCIT_C87728 NCIT_P329 "721764" @default.
- NCIT_C87728 NCIT_P330 "721764" @default.
- NCIT_C87728 NCIT_P350 "C19H20Br2N6O4S" @default.
- NCIT_C87728 NCIT_P375 "Macitentan" @default.
- NCIT_C87728 NCIT_P399 "721764" @default.
- NCIT_C87728 normalizedInformationContent "100" @default.
- NCIT_C87728 referenceCount "1" @default.
- NCIT_C87728 hasExactSynonym "ACT-064992" @default.
- NCIT_C87728 hasExactSynonym "Actelion-1" @default.
- NCIT_C87728 hasExactSynonym "MACITENTAN" @default.
- NCIT_C87728 hasExactSynonym "Macitentan" @default.
- NCIT_C87728 hasExactSynonym "N-(5-(4-Bromophenyl)-6-(2-((5-Bromopyrimidin-2-Yl)Oxi)Ethoxy)Pyrimidin-4-Yl)-N'-Propylsulfuric Diamide" @default.
- NCIT_C87728 inSubset NCIT_C116977 @default.
- NCIT_C87728 inSubset NCIT_C116978 @default.
- NCIT_C87728 inSubset NCIT_C128784 @default.
- NCIT_C87728 inSubset NCIT_C157711 @default.
- NCIT_C87728 inSubset NCIT_C157712 @default.
- NCIT_C87728 inSubset NCIT_C176424 @default.
- NCIT_C87728 inSubset NCIT_C177537 @default.
- NCIT_C87728 inSubset NCIT_C63923 @default.
- NCIT_C87728 type Class @default.
- NCIT_C87728 isDefinedBy ncit.owl @default.
- NCIT_C87728 label "Macitentan" @default.
- NCIT_C87728 subClassOf NCIT_C1908 @default.
- NCIT_C87728 subClassOf NCIT_C1909 @default.
- NCIT_C87728 subClassOf NCIT_C28313 @default.
- NCIT_C87728 subClassOf NCIT_C87728 @default.