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- NCIT_C87837 IAO_0000115 "The orally bioavailable mesylate salt of the 17-allylaminogeldanamycin (17-AAG) small-molecule inhibitor of several receptor protein tyrosine kinases with potential antiangiogenic and antineoplastic activities. Telatinib binds to and inhibits the vascular endothelial growth factor receptors (VEGFRs) type 2 and 3, platelet-derived growth factor receptor beta (PDGFRb) and c-Kit, which may result in the inhibition of angiogenesis and cellular proliferation in tumors in which these receptors are upregulated. These telatinib-inhibited receptor protein tyrosine kinases are overexpressed or mutated in many tumor cell types and may play key roles in tumor angiogenesis and tumor cell proliferation. 17-AAG is a synthetic analogue of the benzoquinone ansamycin antibiotic geldanamycin and has also been found to inhibit the molecular chaperone Hsp90." @default.
- NCIT_C87837 NCIT_A32 NCIT_C1909 @default.
- NCIT_C87837 NCIT_A6 NCIT_C80869 @default.
- NCIT_C87837 NCIT_A7 NCIT_C17328 @default.
- NCIT_C87837 NCIT_A7 NCIT_C26203 @default.
- NCIT_C87837 NCIT_A7 NCIT_C28496 @default.
- NCIT_C87837 NCIT_A7 NCIT_C30164 @default.
- NCIT_C87837 NCIT_NHC0 "C87837" @default.
- NCIT_C87837 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C87837 NCIT_P107 "Telatinib Mesylate" @default.
- NCIT_C87837 NCIT_P108 "Telatinib Mesylate" @default.
- NCIT_C87837 NCIT_P208 "CL415590" @default.
- NCIT_C87837 NCIT_P210 "332013-26-0" @default.
- NCIT_C87837 NCIT_P319 "571LVA9UMS" @default.
- NCIT_C87837 NCIT_P322 "CTRP" @default.
- NCIT_C87837 NCIT_P322 "FDA" @default.
- NCIT_C87837 NCIT_P322 "GDC" @default.
- NCIT_C87837 NCIT_P329 "652798" @default.
- NCIT_C87837 NCIT_P330 "652798" @default.
- NCIT_C87837 NCIT_P375 "Telatinib Mesylate" @default.
- NCIT_C87837 NCIT_P399 "652798" @default.
- NCIT_C87837 normalizedInformationContent "100" @default.
- NCIT_C87837 referenceCount "1" @default.
- NCIT_C87837 hasExactSynonym "17-Demethoxy-17-Allylaminogeldanamycin Mesylate" @default.
- NCIT_C87837 hasExactSynonym "TELATINIB MESYLATE" @default.
- NCIT_C87837 hasExactSynonym "Telatinib Mesylate" @default.
- NCIT_C87837 inSubset NCIT_C116977 @default.
- NCIT_C87837 inSubset NCIT_C116978 @default.
- NCIT_C87837 inSubset NCIT_C128784 @default.
- NCIT_C87837 inSubset NCIT_C157711 @default.
- NCIT_C87837 inSubset NCIT_C157712 @default.
- NCIT_C87837 inSubset NCIT_C176424 @default.
- NCIT_C87837 inSubset NCIT_C177537 @default.
- NCIT_C87837 inSubset NCIT_C63923 @default.
- NCIT_C87837 type Class @default.
- NCIT_C87837 isDefinedBy ncit.owl @default.
- NCIT_C87837 label "Telatinib Mesylate" @default.
- NCIT_C87837 subClassOf NCIT_C129824 @default.
- NCIT_C87837 subClassOf NCIT_C129825 @default.
- NCIT_C87837 subClassOf NCIT_C1404 @default.
- NCIT_C87837 subClassOf NCIT_C1742 @default.
- NCIT_C87837 subClassOf NCIT_C1908 @default.
- NCIT_C87837 subClassOf NCIT_C1909 @default.
- NCIT_C87837 subClassOf NCIT_C1967 @default.
- NCIT_C87837 subClassOf NCIT_C2189 @default.
- NCIT_C87837 subClassOf NCIT_C274 @default.
- NCIT_C87837 subClassOf NCIT_C471 @default.
- NCIT_C87837 subClassOf NCIT_C87837 @default.