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- NCIT_C88055 IAO_0000115 "A preparation of autologous peripheral blood T-lymphocytes (PBTL) that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) coupled to the costimulatory signaling domain CD28 and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3 zeta), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19-CAR retroviral vector-transduced autologous T cells direct the T-lymphocytes to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the TCR/CD3 complex, which regulates both the assembly of complete TCR complexes and their expression on the cell surface. CD28 is essential for CD4+ T-cell proliferation, interleukin-2 production, and T-helper type-2 (Th2) development." @default.
- NCIT_C88055 NCIT_A7 NCIT_C38894 @default.
- NCIT_C88055 NCIT_NHC0 "C88055" @default.
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- NCIT_C88055 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C88055 NCIT_P107 "Anti-CD19-CAR Retroviral Vector-Transduced Autologous T Cells" @default.
- NCIT_C88055 NCIT_P108 "Anti-CD19-CAR Retroviral Vector-Transduced Autologous T Cells" @default.
- NCIT_C88055 NCIT_P208 "CL412378" @default.
- NCIT_C88055 NCIT_P322 "CTRP" @default.
- NCIT_C88055 NCIT_P329 "649012" @default.
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- NCIT_C88055 normalizedInformationContent "100" @default.
- NCIT_C88055 referenceCount "1" @default.
- NCIT_C88055 hasExactSynonym "Anti-CD19-CAR Retroviral Vector-Transduced Autologous T Cells" @default.
- NCIT_C88055 inSubset NCIT_C116977 @default.
- NCIT_C88055 inSubset NCIT_C116978 @default.
- NCIT_C88055 inSubset NCIT_C128784 @default.
- NCIT_C88055 inSubset NCIT_C176424 @default.
- NCIT_C88055 type Class @default.
- NCIT_C88055 isDefinedBy ncit.owl @default.
- NCIT_C88055 label "Anti-CD19-CAR Retroviral Vector-Transduced Autologous T Cells" @default.
- NCIT_C88055 subClassOf NCIT_C129820 @default.
- NCIT_C88055 subClassOf NCIT_C129821 @default.
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- NCIT_C88055 subClassOf NCIT_C308 @default.
- NCIT_C88055 subClassOf NCIT_C88055 @default.