Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C88270> ?p ?o ?g. }
Showing items 1 to 46 of
46
with 100 items per page.
- NCIT_C88270 IAO_0000115 "A small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity. Omipalisib binds to and inhibits PI3K in the PI3K/mTOR signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability and inducing apoptotic cell death. Bax is a member of the proapoptotic Bcl2 family of proteins. PI3K, often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival." @default.
- NCIT_C88270 NCIT_A32 NCIT_C1909 @default.
- NCIT_C88270 NCIT_A7 NCIT_C17270 @default.
- NCIT_C88270 NCIT_NHC0 "C88270" @default.
- NCIT_C88270 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C88270 NCIT_P107 "Omipalisib" @default.
- NCIT_C88270 NCIT_P108 "Omipalisib" @default.
- NCIT_C88270 NCIT_P207 "C2981793" @default.
- NCIT_C88270 NCIT_P210 "1086062-66-9" @default.
- NCIT_C88270 NCIT_P319 "1X8F5A3NA0" @default.
- NCIT_C88270 NCIT_P322 "CTRP" @default.
- NCIT_C88270 NCIT_P322 "FDA" @default.
- NCIT_C88270 NCIT_P322 "GDC" @default.
- NCIT_C88270 NCIT_P329 "655580" @default.
- NCIT_C88270 NCIT_P330 "655580" @default.
- NCIT_C88270 NCIT_P375 "Omipalisib" @default.
- NCIT_C88270 NCIT_P399 "655580" @default.
- NCIT_C88270 normalizedInformationContent "100" @default.
- NCIT_C88270 referenceCount "1" @default.
- NCIT_C88270 hasExactSynonym "Benzenesulfonamide, 2,4-Difluoro-N-(2-methoxy-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)-" @default.
- NCIT_C88270 hasExactSynonym "GSK2126458" @default.
- NCIT_C88270 hasExactSynonym "OMIPALISIB" @default.
- NCIT_C88270 hasExactSynonym "Omipalisib" @default.
- NCIT_C88270 inSubset NCIT_C116977 @default.
- NCIT_C88270 inSubset NCIT_C116978 @default.
- NCIT_C88270 inSubset NCIT_C128784 @default.
- NCIT_C88270 inSubset NCIT_C157711 @default.
- NCIT_C88270 inSubset NCIT_C157712 @default.
- NCIT_C88270 inSubset NCIT_C176424 @default.
- NCIT_C88270 inSubset NCIT_C177537 @default.
- NCIT_C88270 inSubset NCIT_C63923 @default.
- NCIT_C88270 type Class @default.
- NCIT_C88270 isDefinedBy ncit.owl @default.
- NCIT_C88270 label "Omipalisib" @default.
- NCIT_C88270 subClassOf NCIT_C129824 @default.
- NCIT_C88270 subClassOf NCIT_C129825 @default.
- NCIT_C88270 subClassOf NCIT_C1404 @default.
- NCIT_C88270 subClassOf NCIT_C163758 @default.
- NCIT_C88270 subClassOf NCIT_C1742 @default.
- NCIT_C88270 subClassOf NCIT_C1908 @default.
- NCIT_C88270 subClassOf NCIT_C1909 @default.
- NCIT_C88270 subClassOf NCIT_C2152 @default.
- NCIT_C88270 subClassOf NCIT_C2189 @default.
- NCIT_C88270 subClassOf NCIT_C274 @default.
- NCIT_C88270 subClassOf NCIT_C471 @default.
- NCIT_C88270 subClassOf NCIT_C88270 @default.