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- NCIT_C88279 IAO_0000115 "A cancer vaccine comprised of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the suicide gene FCU1 with potential antineoplastic activity. FCU1 is a bifunctional yeast cytosine deaminase (CD) / uracil phosphoribosyltransferase (UPRT) fusion gene. Upon intratumoral administration, MVA-FCU1TG4023 enters tumor cells where FCU1 is expressed. Subsequently, the noncytotoxic prodrug 5-fluorocytosine (5-FC) is administered systemically and is deaminated by CD in FCU1- transduced tumor cells into 5-fluorouracil (5-FU), which is then directly metabolized to 5-fluoro-uridine monophosphate (5-FUMP) by UPRT; 5-FUMP may then be further transformed to 5-fluoro-deoxyuridine monophosphate (5-FdUMP), an irreversible inhibitor of thymidylate synthase and, so, DNA synthesis through deprivation of deoxythymidine triphosphate (dTTP). 5-FU and its active metabolites may then selectively kill tumor cells, avoiding toxicity in nonmalignant cells. The MVA viral vector, derived from the replication-competent strain Ankara, is a highly attenuated, replication-defective vaccinia strain incapable of virion assembly." @default.
- NCIT_C88279 NCIT_A32 NCIT_C1909 @default.
- NCIT_C88279 NCIT_NHC0 "C88279" @default.
- NCIT_C88279 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C88279 NCIT_P108 "MVA-FCU1 TG4023" @default.
- NCIT_C88279 NCIT_P208 "CL412469" @default.
- NCIT_C88279 NCIT_P322 "GDC" @default.
- NCIT_C88279 NCIT_P329 "656523" @default.
- NCIT_C88279 NCIT_P330 "656523" @default.
- NCIT_C88279 NCIT_P375 "MVA-FCU1 TG4023" @default.
- NCIT_C88279 NCIT_P399 "656523" @default.
- NCIT_C88279 normalizedInformationContent "100" @default.
- NCIT_C88279 referenceCount "1" @default.
- NCIT_C88279 hasExactSynonym "MVA-FCU1 TG4023" @default.
- NCIT_C88279 hasExactSynonym "Modified Ankara Virus-Mediated Suicide Gene Delivery Vector TG4023" @default.
- NCIT_C88279 hasExactSynonym "TG4023" @default.
- NCIT_C88279 inSubset NCIT_C128784 @default.
- NCIT_C88279 inSubset NCIT_C157711 @default.
- NCIT_C88279 inSubset NCIT_C157712 @default.
- NCIT_C88279 inSubset NCIT_C176424 @default.
- NCIT_C88279 inSubset NCIT_C177537 @default.
- NCIT_C88279 type Class @default.
- NCIT_C88279 isDefinedBy ncit.owl @default.
- NCIT_C88279 label "MVA-FCU1 TG4023" @default.
- NCIT_C88279 subClassOf NCIT_C1572 @default.
- NCIT_C88279 subClassOf NCIT_C1908 @default.
- NCIT_C88279 subClassOf NCIT_C1909 @default.
- NCIT_C88279 subClassOf NCIT_C1962 @default.
- NCIT_C88279 subClassOf NCIT_C2313 @default.
- NCIT_C88279 subClassOf NCIT_C307 @default.
- NCIT_C88279 subClassOf NCIT_C308 @default.
- NCIT_C88279 subClassOf NCIT_C88279 @default.
- NCIT_C88279 subClassOf NCIT_C923 @default.
- NCIT_C88279 subClassOf NCIT_C96404 @default.