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- NCIT_C88301 IAO_0000115 "A fusion protein containing angiopoietin-2 (Ang2) and vascular endothelial growth factor (VEGF) derived peptides covalently attached, via a proprietary diketone linker, to a proprietary humanized catalytic aldolase monoclonal antibody, with potential antiangiogenic and antineoplastic activities. The Ang2/VEGF peptide moieties of Ang2/VEGF-binding peptides-antibody fusion protein CVX-241 bind to Ang2 and VEGF receptors, which may inhibit tumor angiogenesis and tumor cell proliferation. The proprietary humanized catalytic IgG1 monoclonal aldolase antibody contains reactive lysine residues in its binding sites, which react covalently with compounds having a diketone function; the Ang2 and VEGFR peptide moieties are then covalently attached to the diketone linkers via a proprietary spacer. Both VEGF and Ang2 are upregulated in a variety of cancer cell types and play a crucial role in angiogenesis. This agent possesses an enhanced half-life compared to the naked peptides." @default.
- NCIT_C88301 NCIT_A32 NCIT_C1909 @default.
- NCIT_C88301 NCIT_A7 NCIT_C17293 @default.
- NCIT_C88301 NCIT_A7 NCIT_C18488 @default.
- NCIT_C88301 NCIT_NHC0 "C88301" @default.
- NCIT_C88301 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C88301 NCIT_P107 "Ang2/VEGF-Binding Peptides-Antibody Fusion Protein CVX-241" @default.
- NCIT_C88301 NCIT_P108 "Ang2/VEGF-Binding Peptides-Antibody Fusion Protein CVX-241" @default.
- NCIT_C88301 NCIT_P208 "CL413555" @default.
- NCIT_C88301 NCIT_P210 "1415642-63-5" @default.
- NCIT_C88301 NCIT_P319 "3RM68C5CTG" @default.
- NCIT_C88301 NCIT_P322 "CTRP" @default.
- NCIT_C88301 NCIT_P322 "FDA" @default.
- NCIT_C88301 NCIT_P322 "GDC" @default.
- NCIT_C88301 NCIT_P329 "659158" @default.
- NCIT_C88301 NCIT_P330 "659158" @default.
- NCIT_C88301 NCIT_P375 "Ang2/VEGF-Binding Peptides-Antibody Fusion Protein CVX-241" @default.
- NCIT_C88301 NCIT_P399 "659158" @default.
- NCIT_C88301 normalizedInformationContent "100" @default.
- NCIT_C88301 referenceCount "1" @default.
- NCIT_C88301 hasExactSynonym "Ang2/VEGF-Binding Peptides-Antibody Fusion Protein CVX-241" @default.
- NCIT_C88301 hasExactSynonym "CVX-241" @default.
- NCIT_C88301 hasExactSynonym "PF-05057459" @default.
- NCIT_C88301 inSubset NCIT_C116977 @default.
- NCIT_C88301 inSubset NCIT_C116978 @default.
- NCIT_C88301 inSubset NCIT_C128784 @default.
- NCIT_C88301 inSubset NCIT_C157711 @default.
- NCIT_C88301 inSubset NCIT_C157712 @default.
- NCIT_C88301 inSubset NCIT_C176424 @default.
- NCIT_C88301 inSubset NCIT_C177537 @default.
- NCIT_C88301 inSubset NCIT_C63923 @default.
- NCIT_C88301 type Class @default.
- NCIT_C88301 isDefinedBy ncit.owl @default.
- NCIT_C88301 label "Ang2/VEGF-Binding Peptides-Antibody Fusion Protein CVX-241" @default.
- NCIT_C88301 subClassOf NCIT_C1512 @default.
- NCIT_C88301 subClassOf NCIT_C163758 @default.
- NCIT_C88301 subClassOf NCIT_C1742 @default.
- NCIT_C88301 subClassOf NCIT_C1908 @default.
- NCIT_C88301 subClassOf NCIT_C1909 @default.
- NCIT_C88301 subClassOf NCIT_C198860 @default.
- NCIT_C88301 subClassOf NCIT_C274 @default.
- NCIT_C88301 subClassOf NCIT_C307 @default.
- NCIT_C88301 subClassOf NCIT_C308 @default.
- NCIT_C88301 subClassOf NCIT_C88301 @default.