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- NCIT_C88303 IAO_0000115 "A small-molecule receptor tyrosine kinase (RTK) inhibitor of proto-oncogene receptor tyrosine kinase (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), with antineoplastic activity. Upon oral administration, pexidartinib targets, binds to and inhibits phosphorylation of KIT, CSF1R and FLT3 harboring an internal tandem duplication (ITD) mutation. This results in the inhibition of tumor cell proliferation. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis." @default.
- NCIT_C88303 NCIT_A32 NCIT_C1909 @default.
- NCIT_C88303 NCIT_A5 NCIT_C170314 @default.
- NCIT_C88303 NCIT_A7 NCIT_C17328 @default.
- NCIT_C88303 NCIT_A7 NCIT_C17392 @default.
- NCIT_C88303 NCIT_A7 NCIT_C26202 @default.
- NCIT_C88303 NCIT_NHC0 "C88303" @default.
- NCIT_C88303 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C88303 NCIT_P107 "Pexidartinib" @default.
- NCIT_C88303 NCIT_P108 "Pexidartinib" @default.
- NCIT_C88303 NCIT_P207 "C2981820" @default.
- NCIT_C88303 NCIT_P210 "1029044-16-3" @default.
- NCIT_C88303 NCIT_P319 "6783M2LV5X" @default.
- NCIT_C88303 NCIT_P322 "CTRP" @default.
- NCIT_C88303 NCIT_P322 "FDA" @default.
- NCIT_C88303 NCIT_P322 "GDC" @default.
- NCIT_C88303 NCIT_P375 "Pexidartinib" @default.
- NCIT_C88303 normalizedInformationContent "100" @default.
- NCIT_C88303 referenceCount "1" @default.
- NCIT_C88303 hasExactSynonym "3-Pyridinemethanamine, N-(5-((5-chloro-1H-pyrrolo(2,3-b)pyridin-3-yl)methyl)-2-pyridinyl)-6-(trifluoromethyl)-" @default.
- NCIT_C88303 hasExactSynonym "CML-261" @default.
- NCIT_C88303 hasExactSynonym "PEXIDARTINIB" @default.
- NCIT_C88303 hasExactSynonym "PLX3397" @default.
- NCIT_C88303 hasExactSynonym "Pexidartinib" @default.
- NCIT_C88303 inSubset NCIT_C116977 @default.
- NCIT_C88303 inSubset NCIT_C116978 @default.
- NCIT_C88303 inSubset NCIT_C128784 @default.
- NCIT_C88303 inSubset NCIT_C157711 @default.
- NCIT_C88303 inSubset NCIT_C157712 @default.
- NCIT_C88303 inSubset NCIT_C177537 @default.
- NCIT_C88303 inSubset NCIT_C63923 @default.
- NCIT_C88303 type Class @default.
- NCIT_C88303 isDefinedBy ncit.owl @default.
- NCIT_C88303 label "Pexidartinib" @default.
- NCIT_C88303 subClassOf NCIT_C129824 @default.
- NCIT_C88303 subClassOf NCIT_C129825 @default.
- NCIT_C88303 subClassOf NCIT_C1404 @default.
- NCIT_C88303 subClassOf NCIT_C1908 @default.
- NCIT_C88303 subClassOf NCIT_C1909 @default.
- NCIT_C88303 subClassOf NCIT_C1967 @default.
- NCIT_C88303 subClassOf NCIT_C2189 @default.
- NCIT_C88303 subClassOf NCIT_C274 @default.
- NCIT_C88303 subClassOf NCIT_C471 @default.
- NCIT_C88303 subClassOf NCIT_C88303 @default.