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- NCIT_C88312 IAO_0000115 "The maleate salt form of milciclib, an orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and tropomyosin receptor kinase A (TRKA), with potential antineoplastic activity. CDK2/TRKA inhibitor PHA-848125 AC potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits activity against other CDKs including CDK1 and CDK4, in addition to TRKA. Inhibition of these kinases may result in cell cycle arrest and apoptosis of tumor cells that express these kinases. CDKs are serine/threonine kinases involved in regulation of the cell cycle and may be overexpressed in some cancer cell types. The neurotrophin receptor TRKA is mutated in a variety of cancer cell types." @default.
- NCIT_C88312 NCIT_A32 NCIT_C1909 @default.
- NCIT_C88312 NCIT_NHC0 "C88312" @default.
- NCIT_C88312 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C88312 NCIT_P108 "Milciclib Maleate" @default.
- NCIT_C88312 NCIT_P207 "C2934615" @default.
- NCIT_C88312 NCIT_P210 "1253645-38-3" @default.
- NCIT_C88312 NCIT_P319 "82W826FL6S" @default.
- NCIT_C88312 NCIT_P322 "FDA" @default.
- NCIT_C88312 NCIT_P322 "GDC" @default.
- NCIT_C88312 NCIT_P329 "660138" @default.
- NCIT_C88312 NCIT_P330 "660138" @default.
- NCIT_C88312 NCIT_P375 "Milciclib Maleate" @default.
- NCIT_C88312 NCIT_P399 "660138" @default.
- NCIT_C88312 normalizedInformationContent "100" @default.
- NCIT_C88312 referenceCount "1" @default.
- NCIT_C88312 hasExactSynonym "1H-Pyrazolo(4,3-H)quinazoline-3-carboxamide, 4,5-dihydro-N,1,4,4-tetramethyl-8-((4-(4-methyl-1-piperazinyl)phenyl)amino)-, (2Z)-2-Butenedioate (1:1)" @default.
- NCIT_C88312 hasExactSynonym "MILCICLIB MALEATE" @default.
- NCIT_C88312 hasExactSynonym "Milciclib Maleate" @default.
- NCIT_C88312 hasExactSynonym "N,1,4,4-Tetramethyl-8-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide" @default.
- NCIT_C88312 hasExactSynonym "PHA-848125 AC" @default.
- NCIT_C88312 inSubset NCIT_C128784 @default.
- NCIT_C88312 inSubset NCIT_C157711 @default.
- NCIT_C88312 inSubset NCIT_C157712 @default.
- NCIT_C88312 inSubset NCIT_C176424 @default.
- NCIT_C88312 inSubset NCIT_C177537 @default.
- NCIT_C88312 inSubset NCIT_C63923 @default.
- NCIT_C88312 type Class @default.
- NCIT_C88312 isDefinedBy ncit.owl @default.
- NCIT_C88312 label "Milciclib Maleate" @default.
- NCIT_C88312 subClassOf NCIT_C129824 @default.
- NCIT_C88312 subClassOf NCIT_C129825 @default.
- NCIT_C88312 subClassOf NCIT_C1404 @default.
- NCIT_C88312 subClassOf NCIT_C155765 @default.
- NCIT_C88312 subClassOf NCIT_C163758 @default.
- NCIT_C88312 subClassOf NCIT_C1908 @default.
- NCIT_C88312 subClassOf NCIT_C1909 @default.
- NCIT_C88312 subClassOf NCIT_C192741 @default.
- NCIT_C88312 subClassOf NCIT_C1967 @default.
- NCIT_C88312 subClassOf NCIT_C200052 @default.
- NCIT_C88312 subClassOf NCIT_C2185 @default.
- NCIT_C88312 subClassOf NCIT_C2189 @default.
- NCIT_C88312 subClassOf NCIT_C274 @default.
- NCIT_C88312 subClassOf NCIT_C471 @default.
- NCIT_C88312 subClassOf NCIT_C61074 @default.
- NCIT_C88312 subClassOf NCIT_C88312 @default.