Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C88315> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- NCIT_C88315 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of a humanized monoclonal antibody, directed against the extracellular domain of the human CD70 molecule, conjugated to the auristatin analogue monomethyl auristatin phenylalanine (MMAF), with potential antineoplastic activity. The anti-CD70 antibody moiety of vorsetuzumab mafodotin selectively binds to the extracellular domain of CD70 on tumor cell surfaces. Upon internalization, the MMAF moiety is released, binds to tubulin and inhibits its polymerization, which may result in G2/M phase arrest, tumor cell apoptosis and inhibition of cellular proliferation in tumor cells that overexpress CD70. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells." @default.
- NCIT_C88315 NCIT_A32 NCIT_C1909 @default.
- NCIT_C88315 NCIT_A7 NCIT_C104079 @default.
- NCIT_C88315 NCIT_NHC0 "C88315" @default.
- NCIT_C88315 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C88315 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C88315 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C88315 NCIT_P107 "Vorsetzumab Mafodotin" @default.
- NCIT_C88315 NCIT_P108 "Vorsetzumab Mafodotin" @default.
- NCIT_C88315 NCIT_P208 "CL413570" @default.
- NCIT_C88315 NCIT_P210 "1165741-01-4" @default.
- NCIT_C88315 NCIT_P319 "699619YVTQ" @default.
- NCIT_C88315 NCIT_P322 "CTRP" @default.
- NCIT_C88315 NCIT_P322 "FDA" @default.
- NCIT_C88315 NCIT_P322 "GDC" @default.
- NCIT_C88315 NCIT_P329 "660730" @default.
- NCIT_C88315 NCIT_P330 "660730" @default.
- NCIT_C88315 NCIT_P375 "Vorsetzumab Mafodotin" @default.
- NCIT_C88315 NCIT_P399 "660730" @default.
- NCIT_C88315 normalizedInformationContent "100" @default.
- NCIT_C88315 referenceCount "1" @default.
- NCIT_C88315 hasExactSynonym "Anti-CD70 MoAb SGN70-MMAF Conjugate" @default.
- NCIT_C88315 hasExactSynonym "SGN 75" @default.
- NCIT_C88315 hasExactSynonym "SGN-75" @default.
- NCIT_C88315 hasExactSynonym "VORSETUZUMAB MAFODOTIN" @default.
- NCIT_C88315 hasExactSynonym "Vorsetzumab Mafodotin" @default.
- NCIT_C88315 inSubset NCIT_C116977 @default.
- NCIT_C88315 inSubset NCIT_C116978 @default.
- NCIT_C88315 inSubset NCIT_C128784 @default.
- NCIT_C88315 inSubset NCIT_C157711 @default.
- NCIT_C88315 inSubset NCIT_C157712 @default.
- NCIT_C88315 inSubset NCIT_C176424 @default.
- NCIT_C88315 inSubset NCIT_C177537 @default.
- NCIT_C88315 inSubset NCIT_C63923 @default.
- NCIT_C88315 type Class @default.
- NCIT_C88315 isDefinedBy ncit.owl @default.
- NCIT_C88315 label "Vorsetzumab Mafodotin" @default.
- NCIT_C88315 subClassOf NCIT_C129821 @default.
- NCIT_C88315 subClassOf NCIT_C129823 @default.
- NCIT_C88315 subClassOf NCIT_C1512 @default.
- NCIT_C88315 subClassOf NCIT_C163758 @default.
- NCIT_C88315 subClassOf NCIT_C1908 @default.
- NCIT_C88315 subClassOf NCIT_C1909 @default.
- NCIT_C88315 subClassOf NCIT_C200042 @default.
- NCIT_C88315 subClassOf NCIT_C201550 @default.
- NCIT_C88315 subClassOf NCIT_C274 @default.
- NCIT_C88315 subClassOf NCIT_C307 @default.
- NCIT_C88315 subClassOf NCIT_C308 @default.
- NCIT_C88315 subClassOf NCIT_C88315 @default.