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- NCIT_C88333 IAO_0000115 "An orally bioavailable, small-molecule gamma secretase (GS) inhibitor with potential antitumor activity. Gamma secretase inhibitor RO4929097 binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth." @default.
- NCIT_C88333 NCIT_A32 NCIT_C1909 @default.
- NCIT_C88333 NCIT_A7 NCIT_C95114 @default.
- NCIT_C88333 NCIT_NHC0 "C88333" @default.
- NCIT_C88333 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C88333 NCIT_P107 "Gamma-Secretase Inhibitor RO4929097" @default.
- NCIT_C88333 NCIT_P108 "Gamma-Secretase Inhibitor RO4929097" @default.
- NCIT_C88333 NCIT_P207 "C2742210" @default.
- NCIT_C88333 NCIT_P210 "847925-91-1" @default.
- NCIT_C88333 NCIT_P319 "KK8645V7LE" @default.
- NCIT_C88333 NCIT_P322 "CTRP" @default.
- NCIT_C88333 NCIT_P322 "FDA" @default.
- NCIT_C88333 NCIT_P322 "GDC" @default.
- NCIT_C88333 NCIT_P325 "A substance being studied in the treatment of cancer. It blocks certain enzymes that are needed for cell growth. This may slow the growth of cancer cells. It may also decrease the growth of new blood vessels that tumors need to grow. It is a type of gamma-secretase inhibitor and a type of Notch signaling inhibitor." @default.
- NCIT_C88333 NCIT_P329 "662240" @default.
- NCIT_C88333 NCIT_P330 "662240" @default.
- NCIT_C88333 NCIT_P375 "Gamma-Secretase Inhibitor RO4929097" @default.
- NCIT_C88333 NCIT_P399 "662240" @default.
- NCIT_C88333 normalizedInformationContent "100" @default.
- NCIT_C88333 referenceCount "1" @default.
- NCIT_C88333 hasExactSynonym "Gamma-Secretase Inhibitor RO4929097" @default.
- NCIT_C88333 hasExactSynonym "R04929097" @default.
- NCIT_C88333 hasExactSynonym "RG-4733" @default.
- NCIT_C88333 hasExactSynonym "RO4929097" @default.
- NCIT_C88333 inSubset NCIT_C116977 @default.
- NCIT_C88333 inSubset NCIT_C116978 @default.
- NCIT_C88333 inSubset NCIT_C128784 @default.
- NCIT_C88333 inSubset NCIT_C157711 @default.
- NCIT_C88333 inSubset NCIT_C157712 @default.
- NCIT_C88333 inSubset NCIT_C176424 @default.
- NCIT_C88333 inSubset NCIT_C177537 @default.
- NCIT_C88333 inSubset NCIT_C63923 @default.
- NCIT_C88333 type Class @default.
- NCIT_C88333 isDefinedBy ncit.owl @default.
- NCIT_C88333 label "Gamma-Secretase Inhibitor RO4929097" @default.
- NCIT_C88333 subClassOf NCIT_C1908 @default.
- NCIT_C88333 subClassOf NCIT_C1909 @default.
- NCIT_C88333 subClassOf NCIT_C200529 @default.
- NCIT_C88333 subClassOf NCIT_C471 @default.
- NCIT_C88333 subClassOf NCIT_C783 @default.
- NCIT_C88333 subClassOf NCIT_C88333 @default.