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- NCIT_C88337 IAO_0000115 "A topical formulation of the small-molecule Smoothened (Smo) antagonist LDE225 with potential antineoplastic activity. Upon topical application, smoothened antagonist LDE225 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Inappropriate activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo." @default.
- NCIT_C88337 NCIT_A32 NCIT_C1909 @default.
- NCIT_C88337 NCIT_NHC0 "C88337" @default.
- NCIT_C88337 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C88337 NCIT_P108 "Smoothened Antagonist LDE225 Topical" @default.
- NCIT_C88337 NCIT_P208 "CL413601" @default.
- NCIT_C88337 NCIT_P322 "GDC" @default.
- NCIT_C88337 NCIT_P329 "662542" @default.
- NCIT_C88337 NCIT_P330 "662542" @default.
- NCIT_C88337 NCIT_P375 "Smoothened Antagonist LDE225 Topical" @default.
- NCIT_C88337 NCIT_P399 "662542" @default.
- NCIT_C88337 normalizedInformationContent "100" @default.
- NCIT_C88337 referenceCount "1" @default.
- NCIT_C88337 hasExactSynonym "LDE225" @default.
- NCIT_C88337 hasExactSynonym "Smoothened Antagonist LDE225 Topical" @default.
- NCIT_C88337 inSubset NCIT_C128784 @default.
- NCIT_C88337 inSubset NCIT_C157711 @default.
- NCIT_C88337 inSubset NCIT_C157712 @default.
- NCIT_C88337 inSubset NCIT_C176424 @default.
- NCIT_C88337 inSubset NCIT_C177537 @default.
- NCIT_C88337 type Class @default.
- NCIT_C88337 isDefinedBy ncit.owl @default.
- NCIT_C88337 label "Smoothened Antagonist LDE225 Topical" @default.
- NCIT_C88337 subClassOf NCIT_C155725 @default.
- NCIT_C88337 subClassOf NCIT_C163758 @default.
- NCIT_C88337 subClassOf NCIT_C188731 @default.
- NCIT_C88337 subClassOf NCIT_C1908 @default.
- NCIT_C88337 subClassOf NCIT_C1909 @default.
- NCIT_C88337 subClassOf NCIT_C2189 @default.
- NCIT_C88337 subClassOf NCIT_C274 @default.
- NCIT_C88337 subClassOf NCIT_C88337 @default.