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- NCIT_C88342 IAO_0000115 "A synthetic, 21-mer, unmethylated CpG motif-based oligodeoxynucleotide (ODN), with immunostimulatory activity. CpG oligodeoxynucleotide GNKG168 binds to and activates Toll-like receptor 9 (TLR9) and is taken up into cells by endocytosis; once internalized, it may activate numerous signaling transduction pathways resulting in the release of multiple cytokines, such as immunoglobulins (Igs), interferons (IFNs), interleukins (ILs) and tumor necrosis factor (TNF). Through activation of TLR9, this ODN can directly stimulate B-lymphocytes, dendritic and natural killer (NK) cells, resulting in an increase in innate immunity and antibody-dependent cellular cytotoxicity (ADCC). In addition, through the release of IL-12 and IFN, this agent may induce a preferential shift to the T-helper 1(Th1) phenotype resulting in enhanced CD8+ T cell-mediated antitumor cytotoxicity." @default.
- NCIT_C88342 NCIT_A32 NCIT_C1909 @default.
- NCIT_C88342 NCIT_A7 NCIT_C96048 @default.
- NCIT_C88342 NCIT_NHC0 "C88342" @default.
- NCIT_C88342 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C88342 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C88342 NCIT_P107 "CpG Oligodeoxynucleotide GNKG168" @default.
- NCIT_C88342 NCIT_P108 "CpG Oligodeoxynucleotide GNKG168" @default.
- NCIT_C88342 NCIT_P207 "C2981861" @default.
- NCIT_C88342 NCIT_P319 "JK03C8HWHK" @default.
- NCIT_C88342 NCIT_P322 "CTRP" @default.
- NCIT_C88342 NCIT_P322 "FDA" @default.
- NCIT_C88342 NCIT_P322 "GDC" @default.
- NCIT_C88342 NCIT_P329 "662816" @default.
- NCIT_C88342 NCIT_P330 "662816" @default.
- NCIT_C88342 NCIT_P375 "CpG Oligodeoxynucleotide GNKG168" @default.
- NCIT_C88342 NCIT_P399 "662816" @default.
- NCIT_C88342 normalizedInformationContent "100" @default.
- NCIT_C88342 referenceCount "1" @default.
- NCIT_C88342 hasExactSynonym "CpG ODN GNKG168" @default.
- NCIT_C88342 hasExactSynonym "CpG Oligodeoxynucleotide GNKG168" @default.
- NCIT_C88342 hasExactSynonym "GNKG-168" @default.
- NCIT_C88342 hasExactSynonym "GNKG168" @default.
- NCIT_C88342 inSubset NCIT_C116977 @default.
- NCIT_C88342 inSubset NCIT_C116978 @default.
- NCIT_C88342 inSubset NCIT_C128784 @default.
- NCIT_C88342 inSubset NCIT_C157711 @default.
- NCIT_C88342 inSubset NCIT_C157712 @default.
- NCIT_C88342 inSubset NCIT_C176424 @default.
- NCIT_C88342 inSubset NCIT_C177537 @default.
- NCIT_C88342 inSubset NCIT_C63923 @default.
- NCIT_C88342 type Class @default.
- NCIT_C88342 isDefinedBy ncit.owl @default.
- NCIT_C88342 label "CpG Oligodeoxynucleotide GNKG168" @default.
- NCIT_C88342 subClassOf NCIT_C1908 @default.
- NCIT_C88342 subClassOf NCIT_C1909 @default.
- NCIT_C88342 subClassOf NCIT_C2139 @default.
- NCIT_C88342 subClassOf NCIT_C308 @default.
- NCIT_C88342 subClassOf NCIT_C88342 @default.