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- NCIT_C890 IAO_0000115 "A 5-nitroimidazole derivative with antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group in turn is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death." @default.
- NCIT_C890 NCIT_NHC0 "C890" @default.
- NCIT_C890 NCIT_P106 "Organic Chemical" @default.
- NCIT_C890 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C890 NCIT_P108 "Tinidazole" @default.
- NCIT_C890 NCIT_P207 "C0040263" @default.
- NCIT_C890 NCIT_P210 "19387-91-8" @default.
- NCIT_C890 NCIT_P210 "25459-12-5" @default.
- NCIT_C890 NCIT_P319 "033KF7V46H" @default.
- NCIT_C890 NCIT_P322 "FDA" @default.
- NCIT_C890 NCIT_P325 "A drug used to treat protozoal infections, such as amebiasis, giardiasis, and trichomoniasis. It belongs to a family of drugs called antiprotozoal agents. Tinidazole is also being evaluated in the treatment of Helicobacter pylori infections in people with low-grade gastric lymphoma." @default.
- NCIT_C890 NCIT_P329 "43288" @default.
- NCIT_C890 NCIT_P330 "43288" @default.
- NCIT_C890 NCIT_P350 "C8H13N3O4S" @default.
- NCIT_C890 NCIT_P366 "Tinidazole" @default.
- NCIT_C890 NCIT_P368 "CHEBI:63627" @default.
- NCIT_C890 NCIT_P399 "43288" @default.
- NCIT_C890 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C890 referenceCount "2" @default.
- NCIT_C890 hasExactSynonym "Fasigyn" @default.
- NCIT_C890 hasExactSynonym "Simplotan" @default.
- NCIT_C890 hasExactSynonym "TDZ" @default.
- NCIT_C890 hasExactSynonym "TINIDAZOLE" @default.
- NCIT_C890 hasExactSynonym "Tindamax" @default.
- NCIT_C890 hasExactSynonym "Tinidazole" @default.
- NCIT_C890 hasExactSynonym "tinidazole" @default.
- NCIT_C890 inSubset NCIT_C176424 @default.
- NCIT_C890 inSubset NCIT_C63923 @default.
- NCIT_C890 type Class @default.
- NCIT_C890 isDefinedBy ncit.owl @default.
- NCIT_C890 label "Tinidazole" @default.
- NCIT_C890 subClassOf NCIT_C1908 @default.
- NCIT_C890 subClassOf NCIT_C1909 @default.
- NCIT_C890 subClassOf NCIT_C254 @default.
- NCIT_C890 subClassOf NCIT_C276 @default.
- NCIT_C890 subClassOf NCIT_C277 @default.
- NCIT_C890 subClassOf NCIT_C890 @default.