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- NCIT_C904 IAO_0000115 "The hydrochloride salt of trifluoperazine, a phenothiazine derivative and a dopamine, alpha-adrenergic, and anticholinergic antagonist with antipsychotic, anxiolytic, and antiemetic activities. Trifluoperazine blocks central dopamine receptors, which may prevent or mitigate delusions and hallucinations caused by an excess of dopamine; dopamine blockade in the chemoreceptor trigger zone (CTZ) may result in an antiemetic effect. This agent binds to central adrenergic receptors, which may result in anxiolytic effects. Trifluoperazine also functions as a calmodulin inhibitor, elevating cytosolic calcium." @default.
- NCIT_C904 NCIT_A6 NCIT_C62084 @default.
- NCIT_C904 NCIT_NHC0 "C904" @default.
- NCIT_C904 NCIT_P106 "Organic Chemical" @default.
- NCIT_C904 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C904 NCIT_P108 "Trifluoperazine Hydrochloride" @default.
- NCIT_C904 NCIT_P175 "17474" @default.
- NCIT_C904 NCIT_P207 "C0304381" @default.
- NCIT_C904 NCIT_P210 "440-17-5" @default.
- NCIT_C904 NCIT_P319 "6P1Y2SNF5V" @default.
- NCIT_C904 NCIT_P322 "FDA" @default.
- NCIT_C904 NCIT_P329 "40446" @default.
- NCIT_C904 NCIT_P330 "40446" @default.
- NCIT_C904 NCIT_P350 "C21H24F3N3S.2HCl" @default.
- NCIT_C904 NCIT_P366 "Trifluoperazine" @default.
- NCIT_C904 NCIT_P368 "CHEBI:9710" @default.
- NCIT_C904 NCIT_P399 "40446" @default.
- NCIT_C904 normalizedInformationContent "89.350088392419622" @default.
- NCIT_C904 referenceCount "5" @default.
- NCIT_C904 hasExactSynonym "10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine Dihydrochloride" @default.
- NCIT_C904 hasExactSynonym "Eskazine" @default.
- NCIT_C904 hasExactSynonym "Jatroneural" @default.
- NCIT_C904 hasExactSynonym "SKF 5019" @default.
- NCIT_C904 hasExactSynonym "Stelazine" @default.
- NCIT_C904 hasExactSynonym "TRIFLUOPERAZINE HYDROCHLORIDE" @default.
- NCIT_C904 hasExactSynonym "Terfluzine" @default.
- NCIT_C904 hasExactSynonym "Trifluoperazine Dihydrochloride" @default.
- NCIT_C904 hasExactSynonym "Trifluoperazine Hydrochloride" @default.
- NCIT_C904 inSubset NCIT_C176424 @default.
- NCIT_C904 inSubset NCIT_C63923 @default.
- NCIT_C904 type Class @default.
- NCIT_C904 isDefinedBy ncit.owl @default.
- NCIT_C904 label "Trifluoperazine Hydrochloride" @default.
- NCIT_C904 subClassOf NCIT_C1908 @default.
- NCIT_C904 subClassOf NCIT_C1909 @default.
- NCIT_C904 subClassOf NCIT_C267 @default.
- NCIT_C904 subClassOf NCIT_C29710 @default.
- NCIT_C904 subClassOf NCIT_C740 @default.
- NCIT_C904 subClassOf NCIT_C78272 @default.
- NCIT_C904 subClassOf NCIT_C904 @default.