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- NCIT_C90560 IAO_0000115 "A dendritic cell vaccine consisting of dendritic cells (DCs) electroporated with mRNA encoding three adjuvants, CD40 ligand (CD40L), a constitutively active TLR4, and CD70 (all together termed TriMix); coelectroporated with full-length mRNA encoding MAGE-A3, MAGE-C2, Tyrosinase and gp100; and linked to DC-LAMP, with potential immunostimulating activity. Upon vaccination, the DCs may stimulate the immune system to mount an antigen-specific cytotoxic T-lymphocyte (CTL) response against the melanoma antigens. This may decrease cellular proliferation of melanoma cells expressing these antigens. Electroporation with the adjuvants CD40L and TLR4 allows for the generation of mature and active DCs; electroporation with CD70 provides a costimulatory signal to CD27+ naive T cells thereby supporting T-cell proliferation and inhibiting T-cell apoptosis." @default.
- NCIT_C90560 NCIT_NHC0 "C90560" @default.
- NCIT_C90560 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C90560 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C90560 NCIT_P108 "Autologous TriMix-DC Melanoma Vaccine" @default.
- NCIT_C90560 NCIT_P208 "CL416244" @default.
- NCIT_C90560 NCIT_P329 "666843" @default.
- NCIT_C90560 NCIT_P330 "666843" @default.
- NCIT_C90560 NCIT_P399 "666843" @default.
- NCIT_C90560 normalizedInformationContent "100" @default.
- NCIT_C90560 referenceCount "1" @default.
- NCIT_C90560 hasExactSynonym "Autologous TriMix-DC Melanoma Vaccine" @default.
- NCIT_C90560 inSubset NCIT_C176424 @default.
- NCIT_C90560 type Class @default.
- NCIT_C90560 isDefinedBy ncit.owl @default.
- NCIT_C90560 label "Autologous TriMix-DC Melanoma Vaccine" @default.
- NCIT_C90560 subClassOf NCIT_C129820 @default.
- NCIT_C90560 subClassOf NCIT_C1663 @default.
- NCIT_C90560 subClassOf NCIT_C172787 @default.
- NCIT_C90560 subClassOf NCIT_C181141 @default.
- NCIT_C90560 subClassOf NCIT_C1908 @default.
- NCIT_C90560 subClassOf NCIT_C1909 @default.
- NCIT_C90560 subClassOf NCIT_C274 @default.
- NCIT_C90560 subClassOf NCIT_C28308 @default.
- NCIT_C90560 subClassOf NCIT_C28310 @default.
- NCIT_C90560 subClassOf NCIT_C307 @default.
- NCIT_C90560 subClassOf NCIT_C308 @default.
- NCIT_C90560 subClassOf NCIT_C90560 @default.
- NCIT_C90560 subClassOf NCIT_C923 @default.