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- NCIT_C90578 IAO_0000115 "A humanized IgG1 monoclonal antibody directed against the cell surface glycoprotein CD-38 with potential antineoplastic activity. Isatuximab specifically binds to CD38 on CD38-positive tumor cells. This may trigger antitumoral antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and apoptosis eventually leading to cell lysis in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis." @default.
- NCIT_C90578 NCIT_A32 NCIT_C1909 @default.
- NCIT_C90578 NCIT_A7 NCIT_C84323 @default.
- NCIT_C90578 NCIT_NHC0 "C90578" @default.
- NCIT_C90578 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C90578 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C90578 NCIT_P107 "Isatuximab" @default.
- NCIT_C90578 NCIT_P108 "Isatuximab" @default.
- NCIT_C90578 NCIT_P207 "C2983777" @default.
- NCIT_C90578 NCIT_P210 "1461640-62-9" @default.
- NCIT_C90578 NCIT_P319 "R30772KCU0" @default.
- NCIT_C90578 NCIT_P322 "CTRP" @default.
- NCIT_C90578 NCIT_P322 "FDA" @default.
- NCIT_C90578 NCIT_P322 "GDC" @default.
- NCIT_C90578 NCIT_P329 "668181" @default.
- NCIT_C90578 NCIT_P330 "668181" @default.
- NCIT_C90578 NCIT_P375 "Isatuximab" @default.
- NCIT_C90578 NCIT_P399 "668181" @default.
- NCIT_C90578 NCIT_R124 NCIT_C17710 @default.
- NCIT_C90578 NCIT_R124 NCIT_C17828 @default.
- NCIT_C90578 NCIT_R124 NCIT_C18219 @default.
- NCIT_C90578 NCIT_R124 NCIT_C19986 @default.
- NCIT_C90578 NCIT_R124 NCIT_C40474 @default.
- NCIT_C90578 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C90578 referenceCount "3" @default.
- NCIT_C90578 hasExactSynonym "Hu 38SB19" @default.
- NCIT_C90578 hasExactSynonym "ISATUXIMAB" @default.
- NCIT_C90578 hasExactSynonym "Immunoglobulin G1, Anti-(Human CD38 Antigen) (Human-mus musculus Monoclonal HU38SB19 Heavy Chain), Disulfide with Human-mus musculus Monoclonal HU38SB19 Light Chain, Dimer" @default.
- NCIT_C90578 hasExactSynonym "Isatuximab" @default.
- NCIT_C90578 hasExactSynonym "Isatuximab-irfc" @default.
- NCIT_C90578 hasExactSynonym "SAR 650984" @default.
- NCIT_C90578 hasExactSynonym "SAR-650984" @default.
- NCIT_C90578 hasExactSynonym "SAR650984" @default.
- NCIT_C90578 hasExactSynonym "Sarclisa" @default.
- NCIT_C90578 inSubset NCIT_C116977 @default.
- NCIT_C90578 inSubset NCIT_C116978 @default.
- NCIT_C90578 inSubset NCIT_C128784 @default.
- NCIT_C90578 inSubset NCIT_C157711 @default.
- NCIT_C90578 inSubset NCIT_C157712 @default.
- NCIT_C90578 inSubset NCIT_C176424 @default.
- NCIT_C90578 inSubset NCIT_C177537 @default.
- NCIT_C90578 inSubset NCIT_C63923 @default.
- NCIT_C90578 type Class @default.
- NCIT_C90578 isDefinedBy ncit.owl @default.
- NCIT_C90578 label "Isatuximab" @default.
- NCIT_C90578 subClassOf NCIT_C155321 @default.
- NCIT_C90578 subClassOf NCIT_C163758 @default.
- NCIT_C90578 subClassOf NCIT_C164008 @default.
- NCIT_C90578 subClassOf NCIT_C1908 @default.
- NCIT_C90578 subClassOf NCIT_C1909 @default.
- NCIT_C90578 subClassOf NCIT_C20401 @default.
- NCIT_C90578 subClassOf NCIT_C274 @default.
- NCIT_C90578 subClassOf NCIT_C307 @default.
- NCIT_C90578 subClassOf NCIT_C308 @default.
- NCIT_C90578 subClassOf NCIT_C90578 @default.