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- NCIT_C90581 IAO_0000115 "An orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor MK2206 binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents." @default.
- NCIT_C90581 NCIT_A32 NCIT_C1909 @default.
- NCIT_C90581 NCIT_A7 NCIT_C41625 @default.
- NCIT_C90581 NCIT_NHC0 "C90581" @default.
- NCIT_C90581 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C90581 NCIT_P107 "Akt Inhibitor MK2206" @default.
- NCIT_C90581 NCIT_P108 "Akt Inhibitor MK2206" @default.
- NCIT_C90581 NCIT_P207 "C2933427" @default.
- NCIT_C90581 NCIT_P210 "1032349-93-1" @default.
- NCIT_C90581 NCIT_P319 "51HZG6MP1K" @default.
- NCIT_C90581 NCIT_P322 "CTRP" @default.
- NCIT_C90581 NCIT_P322 "FDA" @default.
- NCIT_C90581 NCIT_P322 "GDC" @default.
- NCIT_C90581 NCIT_P325 "An orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor MK2206 binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents" @default.
- NCIT_C90581 NCIT_P329 "596332" @default.
- NCIT_C90581 NCIT_P330 "596332" @default.
- NCIT_C90581 NCIT_P375 "Akt Inhibitor MK2206" @default.
- NCIT_C90581 NCIT_P399 "596332" @default.
- NCIT_C90581 normalizedInformationContent "100" @default.
- NCIT_C90581 referenceCount "1" @default.
- NCIT_C90581 hasExactSynonym "1,2,4-Triazolo(3,4-f)(1,6)naphthyridin-3(2H)-one, 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-" @default.
- NCIT_C90581 hasExactSynonym "Akt Inhibitor MK2206" @default.
- NCIT_C90581 hasExactSynonym "Akt inhibitor MK2206" @default.
- NCIT_C90581 hasExactSynonym "MK 2206" @default.
- NCIT_C90581 hasExactSynonym "MK-2206 FREE BASE" @default.
- NCIT_C90581 hasExactSynonym "MK-2206" @default.
- NCIT_C90581 hasExactSynonym "MK2206" @default.
- NCIT_C90581 inSubset NCIT_C116977 @default.
- NCIT_C90581 inSubset NCIT_C116978 @default.
- NCIT_C90581 inSubset NCIT_C128784 @default.
- NCIT_C90581 inSubset NCIT_C157711 @default.
- NCIT_C90581 inSubset NCIT_C157712 @default.
- NCIT_C90581 inSubset NCIT_C176424 @default.
- NCIT_C90581 inSubset NCIT_C177537 @default.
- NCIT_C90581 inSubset NCIT_C63923 @default.
- NCIT_C90581 type Class @default.
- NCIT_C90581 isDefinedBy ncit.owl @default.
- NCIT_C90581 label "Akt Inhibitor MK2206" @default.
- NCIT_C90581 subClassOf NCIT_C129824 @default.
- NCIT_C90581 subClassOf NCIT_C129825 @default.
- NCIT_C90581 subClassOf NCIT_C1404 @default.
- NCIT_C90581 subClassOf NCIT_C155764 @default.
- NCIT_C90581 subClassOf NCIT_C1742 @default.
- NCIT_C90581 subClassOf NCIT_C1908 @default.
- NCIT_C90581 subClassOf NCIT_C1909 @default.
- NCIT_C90581 subClassOf NCIT_C2189 @default.
- NCIT_C90581 subClassOf NCIT_C274 @default.
- NCIT_C90581 subClassOf NCIT_C471 @default.
- NCIT_C90581 subClassOf NCIT_C61074 @default.
- NCIT_C90581 subClassOf NCIT_C90581 @default.