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- NCIT_C90582 IAO_0000115 "An orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase (17,20 lyase) with potential antiandrogen activity. TAK-700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells. The cytochrome P450 enzyme CYP17A1 (P450C17), localized to the endoplasmic reticulum (ER), exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces steroidal hormones, such as progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens." @default.
- NCIT_C90582 NCIT_A32 NCIT_C1909 @default.
- NCIT_C90582 NCIT_NHC0 "C90582" @default.
- NCIT_C90582 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C90582 NCIT_P107 "Orteronel" @default.
- NCIT_C90582 NCIT_P108 "Orteronel" @default.
- NCIT_C90582 NCIT_P207 "C2983781" @default.
- NCIT_C90582 NCIT_P210 "566939-85-3" @default.
- NCIT_C90582 NCIT_P319 "UE5K2FNS92" @default.
- NCIT_C90582 NCIT_P322 "CTRP" @default.
- NCIT_C90582 NCIT_P322 "FDA" @default.
- NCIT_C90582 NCIT_P322 "GDC" @default.
- NCIT_C90582 NCIT_P329 "583018" @default.
- NCIT_C90582 NCIT_P330 "583018" @default.
- NCIT_C90582 NCIT_P375 "Orteronel" @default.
- NCIT_C90582 NCIT_P399 "583018" @default.
- NCIT_C90582 normalizedInformationContent "100" @default.
- NCIT_C90582 referenceCount "1" @default.
- NCIT_C90582 hasExactSynonym "6-((7S)-7-hydroxy-6,7-dihydro-5h-pyrrolo(1,2-c)imidazol-7-yl)-N-methyl-2-naphthalenecarboxamide" @default.
- NCIT_C90582 hasExactSynonym "Androgen Synthesis Inhibitor TAK-700" @default.
- NCIT_C90582 hasExactSynonym "CYP17A1 Lyase Inhibitor TAK-700" @default.
- NCIT_C90582 hasExactSynonym "ORTERONEL" @default.
- NCIT_C90582 hasExactSynonym "Orteronel" @default.
- NCIT_C90582 hasExactSynonym "TAK-700" @default.
- NCIT_C90582 inSubset NCIT_C116977 @default.
- NCIT_C90582 inSubset NCIT_C116978 @default.
- NCIT_C90582 inSubset NCIT_C128784 @default.
- NCIT_C90582 inSubset NCIT_C157711 @default.
- NCIT_C90582 inSubset NCIT_C157712 @default.
- NCIT_C90582 inSubset NCIT_C176424 @default.
- NCIT_C90582 inSubset NCIT_C177537 @default.
- NCIT_C90582 inSubset NCIT_C63923 @default.
- NCIT_C90582 type Class @default.
- NCIT_C90582 isDefinedBy ncit.owl @default.
- NCIT_C90582 label "Orteronel" @default.
- NCIT_C90582 subClassOf NCIT_C147908 @default.
- NCIT_C90582 subClassOf NCIT_C147923 @default.
- NCIT_C90582 subClassOf NCIT_C1908 @default.
- NCIT_C90582 subClassOf NCIT_C1909 @default.
- NCIT_C90582 subClassOf NCIT_C242 @default.
- NCIT_C90582 subClassOf NCIT_C471 @default.
- NCIT_C90582 subClassOf NCIT_C547 @default.
- NCIT_C90582 subClassOf NCIT_C90582 @default.