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- NCIT_C90585 IAO_0000115 "An orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A, with potential antimitotic and antineoplastic activity. Aurora A kinase inhibitor MK5108 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and eventually inhibition of cell division, proliferation and an induction of apoptosis in cells overexpressing Aurora A kinase. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aurora kinases are overexpressed in a wide variety of cancers." @default.
- NCIT_C90585 NCIT_A32 NCIT_C1909 @default.
- NCIT_C90585 NCIT_A7 NCIT_C30006 @default.
- NCIT_C90585 NCIT_NHC0 "C90585" @default.
- NCIT_C90585 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C90585 NCIT_P107 "Aurora A Kinase Inhibitor MK5108" @default.
- NCIT_C90585 NCIT_P108 "Aurora A Kinase Inhibitor MK5108" @default.
- NCIT_C90585 NCIT_P207 "C2932550" @default.
- NCIT_C90585 NCIT_P210 "1010085-13-8" @default.
- NCIT_C90585 NCIT_P319 "H8J407531S" @default.
- NCIT_C90585 NCIT_P322 "CTRP" @default.
- NCIT_C90585 NCIT_P322 "FDA" @default.
- NCIT_C90585 NCIT_P322 "GDC" @default.
- NCIT_C90585 NCIT_P329 "575529" @default.
- NCIT_C90585 NCIT_P330 "575529" @default.
- NCIT_C90585 NCIT_P375 "Aurora A Kinase Inhibitor MK5108" @default.
- NCIT_C90585 NCIT_P399 "575529" @default.
- NCIT_C90585 NCIT_R146 NCIT_C16554 @default.
- NCIT_C90585 NCIT_R146 NCIT_C16984 @default.
- NCIT_C90585 NCIT_R146 NCIT_C17018 @default.
- NCIT_C90585 NCIT_R146 NCIT_C17021 @default.
- NCIT_C90585 NCIT_R146 NCIT_C17210 @default.
- NCIT_C90585 NCIT_R146 NCIT_C17325 @default.
- NCIT_C90585 NCIT_R146 NCIT_C20027 @default.
- NCIT_C90585 NCIT_R146 NCIT_C26548 @default.
- NCIT_C90585 NCIT_R146 NCIT_C30006 @default.
- NCIT_C90585 normalizedInformationContent "100" @default.
- NCIT_C90585 referenceCount "1" @default.
- NCIT_C90585 hasExactSynonym "Aurora A Kinase Inhibitor MK5108" @default.
- NCIT_C90585 hasExactSynonym "MK 5108" @default.
- NCIT_C90585 hasExactSynonym "MK-5108" @default.
- NCIT_C90585 hasExactSynonym "MK5108" @default.
- NCIT_C90585 inSubset NCIT_C116977 @default.
- NCIT_C90585 inSubset NCIT_C116978 @default.
- NCIT_C90585 inSubset NCIT_C128784 @default.
- NCIT_C90585 inSubset NCIT_C157711 @default.
- NCIT_C90585 inSubset NCIT_C157712 @default.
- NCIT_C90585 inSubset NCIT_C176424 @default.
- NCIT_C90585 inSubset NCIT_C177537 @default.
- NCIT_C90585 inSubset NCIT_C63923 @default.
- NCIT_C90585 type Class @default.
- NCIT_C90585 isDefinedBy ncit.owl @default.
- NCIT_C90585 label "Aurora A Kinase Inhibitor MK5108" @default.
- NCIT_C90585 subClassOf NCIT_C129824 @default.
- NCIT_C90585 subClassOf NCIT_C129825 @default.
- NCIT_C90585 subClassOf NCIT_C1404 @default.
- NCIT_C90585 subClassOf NCIT_C1908 @default.
- NCIT_C90585 subClassOf NCIT_C1909 @default.
- NCIT_C90585 subClassOf NCIT_C2189 @default.
- NCIT_C90585 subClassOf NCIT_C274 @default.
- NCIT_C90585 subClassOf NCIT_C471 @default.
- NCIT_C90585 subClassOf NCIT_C61074 @default.
- NCIT_C90585 subClassOf NCIT_C62556 @default.
- NCIT_C90585 subClassOf NCIT_C90585 @default.