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- NCIT_C90595 IAO_0000115 "An indenoisoquinoline and non-camptothecin inhibitor of topoisomerase I (Top I) with potential antineoplastic activity. Topoisomerase I inhibitor LMP776 binds to the topoisomerase I-DNA covalent cleavage complexes, and inhibits repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations. Compared to camptothecins, indenoisoquinolines are chemically stable, produce stable Top I-DNA cleavage complexes, induce unique DNA cleavage sites and appear more resistant to multidrug efflux pumps." @default.
- NCIT_C90595 NCIT_A32 NCIT_C1909 @default.
- NCIT_C90595 NCIT_A7 NCIT_C16516 @default.
- NCIT_C90595 NCIT_NHC0 "C90595" @default.
- NCIT_C90595 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C90595 NCIT_P107 "Topoisomerase I Inhibitor LMP776" @default.
- NCIT_C90595 NCIT_P108 "Topoisomerase I Inhibitor LMP776" @default.
- NCIT_C90595 NCIT_P208 "CL413611" @default.
- NCIT_C90595 NCIT_P322 "CTRP" @default.
- NCIT_C90595 NCIT_P322 "GDC" @default.
- NCIT_C90595 NCIT_P325 "A substance being studied in the treatment of cancer. It blocks certain enzymes that break and rejoin DNA strands. These enzymes are needed for cells to divide and grow. Blocking them may cause cancer cells to die. LMP776 also helps anticancer drugs kill cancers that are resistant to some other drugs. LMP776 is a type of indenoisoquinoline and a type of topoisomerase inhibitor." @default.
- NCIT_C90595 NCIT_P329 "663025" @default.
- NCIT_C90595 NCIT_P330 "663025" @default.
- NCIT_C90595 NCIT_P375 "Topoisomerase I Inhibitor LMP776" @default.
- NCIT_C90595 NCIT_P399 "663025" @default.
- NCIT_C90595 normalizedInformationContent "100" @default.
- NCIT_C90595 referenceCount "1" @default.
- NCIT_C90595 hasExactSynonym "LMP776" @default.
- NCIT_C90595 hasExactSynonym "Topoisomerase I Inhibitor LMP776" @default.
- NCIT_C90595 inSubset NCIT_C116977 @default.
- NCIT_C90595 inSubset NCIT_C116978 @default.
- NCIT_C90595 inSubset NCIT_C128784 @default.
- NCIT_C90595 inSubset NCIT_C157711 @default.
- NCIT_C90595 inSubset NCIT_C157712 @default.
- NCIT_C90595 inSubset NCIT_C176424 @default.
- NCIT_C90595 inSubset NCIT_C177537 @default.
- NCIT_C90595 type Class @default.
- NCIT_C90595 isDefinedBy ncit.owl @default.
- NCIT_C90595 label "Topoisomerase I Inhibitor LMP776" @default.
- NCIT_C90595 subClassOf NCIT_C129824 @default.
- NCIT_C90595 subClassOf NCIT_C129825 @default.
- NCIT_C90595 subClassOf NCIT_C1748 @default.
- NCIT_C90595 subClassOf NCIT_C1904 @default.
- NCIT_C90595 subClassOf NCIT_C1908 @default.
- NCIT_C90595 subClassOf NCIT_C1909 @default.
- NCIT_C90595 subClassOf NCIT_C2189 @default.
- NCIT_C90595 subClassOf NCIT_C274 @default.
- NCIT_C90595 subClassOf NCIT_C471 @default.
- NCIT_C90595 subClassOf NCIT_C90595 @default.