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- NCIT_C90737 IAO_0000115 "A benzonaphthyridine derivative, with antimalarial and potential antiviral activities. Upon administration, pyronaridine inhibits the formation of beta-hematin, which results in the accumulation of toxic heme within the parasite. In addition, pyronaridine inhibits glutathione-dependent degradation of hematin. This promotes hematin-induced lysis of red blood cells (RBCs), resulting in parasite death. Pyronaridine also exhibits antiviral activity against some viruses in vitro, including Ebola (EBOV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) viruses." @default.
- NCIT_C90737 NCIT_NHC0 "C90737" @default.
- NCIT_C90737 NCIT_P106 "Organic Chemical" @default.
- NCIT_C90737 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C90737 NCIT_P108 "Pyronaridine" @default.
- NCIT_C90737 NCIT_P207 "C0072768" @default.
- NCIT_C90737 NCIT_P210 "74847-35-1" @default.
- NCIT_C90737 NCIT_P319 "TD3P7Q3SG6" @default.
- NCIT_C90737 NCIT_P322 "FDA" @default.
- NCIT_C90737 NCIT_P350 "C29H32ClN5O2" @default.
- NCIT_C90737 normalizedInformationContent "100" @default.
- NCIT_C90737 referenceCount "1" @default.
- NCIT_C90737 hasExactSynonym "PYRONARIDINE" @default.
- NCIT_C90737 hasExactSynonym "Pyronaridine" @default.
- NCIT_C90737 inSubset NCIT_C173381 @default.
- NCIT_C90737 inSubset NCIT_C173383 @default.
- NCIT_C90737 inSubset NCIT_C63923 @default.
- NCIT_C90737 type Class @default.
- NCIT_C90737 isDefinedBy ncit.owl @default.
- NCIT_C90737 label "Pyronaridine" @default.
- NCIT_C90737 subClassOf NCIT_C1908 @default.
- NCIT_C90737 subClassOf NCIT_C1909 @default.
- NCIT_C90737 subClassOf NCIT_C254 @default.
- NCIT_C90737 subClassOf NCIT_C271 @default.
- NCIT_C90737 subClassOf NCIT_C276 @default.
- NCIT_C90737 subClassOf NCIT_C277 @default.
- NCIT_C90737 subClassOf NCIT_C90737 @default.