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- NCIT_C90781 IAO_0000115 "The sulfate salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia." @default.
- NCIT_C90781 NCIT_A6 NCIT_C61632 @default.
- NCIT_C90781 NCIT_NHC0 "C90781" @default.
- NCIT_C90781 NCIT_P106 "Organic Chemical" @default.
- NCIT_C90781 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C90781 NCIT_P108 "Amantadine Sulfate" @default.
- NCIT_C90781 NCIT_P207 "C0002404" @default.
- NCIT_C90781 NCIT_P210 "31377-23-8" @default.
- NCIT_C90781 NCIT_P319 "9921T5P019" @default.
- NCIT_C90781 NCIT_P322 "FDA" @default.
- NCIT_C90781 NCIT_P350 "2C10H17N.H2O4S" @default.
- NCIT_C90781 normalizedInformationContent "100" @default.
- NCIT_C90781 referenceCount "1" @default.
- NCIT_C90781 hasExactSynonym "AMANTADINE SULFATE" @default.
- NCIT_C90781 hasExactSynonym "Amantadine Sulfate" @default.
- NCIT_C90781 inSubset NCIT_C63923 @default.
- NCIT_C90781 type Class @default.
- NCIT_C90781 isDefinedBy ncit.owl @default.
- NCIT_C90781 label "Amantadine Sulfate" @default.
- NCIT_C90781 subClassOf NCIT_C1908 @default.
- NCIT_C90781 subClassOf NCIT_C1909 @default.
- NCIT_C90781 subClassOf NCIT_C254 @default.
- NCIT_C90781 subClassOf NCIT_C281 @default.
- NCIT_C90781 subClassOf NCIT_C90781 @default.
- NCIT_C90781 subClassOf NCIT_C93038 @default.